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dc.contributor.authorBurne, THJ
dc.contributor.authorBecker, A
dc.contributor.authorBrown, J
dc.contributor.authorEyles, DW
dc.contributor.authorMackay-Sim, A
dc.contributor.authorMcGrath, JJ
dc.date.accessioned2017-05-03T11:32:28Z
dc.date.available2017-05-03T11:32:28Z
dc.date.issued2004
dc.date.modified2009-09-22T05:51:43Z
dc.identifier.issn0166-4328
dc.identifier.doi10.1016/j.bbr.2004.03.023
dc.identifier.urihttp://hdl.handle.net/10072/5714
dc.description.abstractRat experiments have shown that prenatal Vitamin D deficiency leads to altered neonatal brain morphology, cell density and neurotrophin expression. In the current study we examined the hypothesis that Vitamin D deficiency during early development alters adult behaviour even when there is an intervening period in which the animal receives normal Vitamin D in later development. Rats were conceived and born to Vitamin D deficient dams (Birth); conceived, born and weaned from Vitamin D deficient dams (Weaning); or deficient in Vitamin D from conception to 10 weeks of age (Life). Litters were standardized to three males and three females per litter. All rat offspring were rendered normocalcaemic with calcium supplemented water (2 mM) after weaning. Control animals were born to mothers fed a normal diet but subject to similar litter size and calcium supplementation. At 10 weeks all animals were tested on the holeboard test, elevated plus maze test, social interaction observation, acoustic startle response test, prepulse inhibition of the acoustic startle response and a forced swim test. Early Vitamin D deficiency (Birth group) enhanced locomotion in the holeboard test and increased activity in the elevated plus maze. Thus, transient prenatal Vitamin D deficiency induces hyperlocomotion in adulthood, without severe motor abnormalities
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherElsevier
dc.publisher.placeLondon
dc.publisher.urihttp://www.sciencedirect.com/science/journal/01664328
dc.relation.ispartofpagefrom549
dc.relation.ispartofpageto555
dc.relation.ispartofjournalBehavioural Brain Research
dc.relation.ispartofvolume154
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchPsychology and Cognitive Sciences
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode17
dc.titleTransient prenatal vitamin D deficiency is associated with hyperlocomotion in adult rats
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorMackay-Sim, Alan
gro.griffith.authorBurne, Thomas HJ.
gro.griffith.authorMcGrath, John J.


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