Show simple item record

dc.contributor.authorKiefel, MJ
dc.contributor.authorvon Itzstein, M
dc.contributor.editorLee, YC
dc.contributor.editorLee, RT
dc.date.accessioned2017-05-03T11:05:53Z
dc.date.available2017-05-03T11:05:53Z
dc.date.issued2003
dc.date.modified2014-08-08T04:06:28Z
dc.identifier.isbn0-12-182266-4
dc.identifier.doi10.1016/S0076-6879(03)01068-1
dc.identifier.urihttp://hdl.handle.net/10072/571
dc.description.abstractThis chapter investigates carbohydrates as inhibitors of rotaviral infection, and discusses strategies towards the development of chemotherapeutic agents for the treatment of rotavirus rather than vaccine strategies. This focuses on efforts directed at developing drug candidates based on the interaction between rotavirus and its host-cell receptor. Two opposing hypotheses that have been proposed about how rotaviruses gain entry into host cells are: through direct entry or fusion and through Ca2+-dependent endocytosis. Much of the conjecture surrounding the host-cell receptor for rotavirus centers on the postulated involvement of particular cell surface carbohydrates, most notably sialic acids [for example, N-acetylneuraminic acid (Neu5Ac, 1) or N-glycolylneuraminic acid (Neu5Gc, 2)]. The binding of rotavirus to host cells has generally been considered as being either dependent on or independent of the presence of sialic acids in host-cell surface glycoconjugates. The inhibition of rotavirus by naturally-derived substances is also discussed. The chapter outlines the methodology related to the development of carbohydrate-based inhibitors of rotavirus such as synthesis of sialylmimetics and biological evaluation of sialylmimetics.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Inc.
dc.publisher.placeSan Diego, USA
dc.publisher.urihttp://www.sciencedirect.com/science/bookseries/00766879/363
dc.relation.ispartofbooktitleRecognition of carbohydrates in biological systems
dc.relation.ispartofchapter30
dc.relation.ispartofpagefrom395
dc.relation.ispartofpageto412
dc.relation.ispartofvolume363
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3101
dc.titleCarbohydrates as Inhibitors of Rotaviral Infection
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.rights.copyrightSelf-archiving is not yet supported by this publisher. Please refer to the publisher's website or contact the author(s) for more information.
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorvon Itzstein, Mark
gro.griffith.authorKiefel, Milton


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Book chapters
    Contains book chapters authored by Griffith authors.

Show simple item record