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dc.contributor.authorBeecham, Ashley H
dc.contributor.authorPatsopoulos, Nikolaos A
dc.contributor.authorXifara, Dionysia K
dc.contributor.authorDavis, Mary F
dc.contributor.authorKemppinen, Anu
dc.contributor.authorCotsapas, Chris
dc.contributor.authorShah, Tejas S
dc.contributor.authorSpencer, Chris
dc.contributor.authorBooth, David
dc.contributor.authorGoris, An
dc.contributor.authorOturai, Annette
dc.contributor.authorSaarela, Janna
dc.contributor.authorFontaine, Bertrand
dc.contributor.authorHemmer, Bernhard
dc.contributor.authorMartin, Claes
dc.contributor.authorZipp, Frauke
dc.contributor.authorD'Alfonso, Sandra
dc.contributor.authorMartinelli-Boneschi, Filippo
dc.contributor.authorTaylor, Bruce
dc.contributor.authorHarbo, Hanne F
dc.contributor.authorKockum, Ingrid
dc.contributor.authorHillert, Jan
dc.contributor.authorOlsson, Tomas
dc.contributor.authorBan, Maria
dc.contributor.authorOksenberg, Jorge R
dc.contributor.authorHintzen, Rogier
dc.contributor.authorBarcellos, Lisa F
dc.contributor.authorAgliardi, Cristina
dc.contributor.authorAlfredsson, Lars
dc.contributor.authorAlizadeh, Mehdi
dc.contributor.authorAnderson, Carl
dc.contributor.authorAndrews, Robert
dc.contributor.authorSondergaard, Helle Bach
dc.contributor.authorBaker, Amie
dc.contributor.authorBand, Gavin
dc.contributor.authorBaranzini, Sergio E
dc.contributor.authorBarizzone, Nadia
dc.contributor.authorBarrett, Jeffrey
dc.contributor.authorBellenguez, Celine
dc.contributor.authorBergamaschi, Laura
dc.contributor.authorBernardinelli, Luisa
dc.contributor.authorBerthele, Achim
dc.contributor.authorBiberacher, Viola
dc.contributor.authorBinder, Thomas MC
dc.contributor.authorBlackburn, Hannah
dc.contributor.authorBomfim, Izaura L
dc.contributor.authorBrambilla, Paola
dc.contributor.authorBroadley, Simon
dc.contributor.authorBrochet, Bruno
dc.contributor.authorBrundin, Lou
dc.contributor.authorBuck, Dorothea
dc.contributor.authorButzkueven, Helmut
dc.contributor.authorCaillier, Stacy J
dc.contributor.authorCamu, William
dc.contributor.authorCarpentier, Wassila
dc.contributor.authorCavalla, Paola
dc.contributor.authorCelius, Elisabeth G
dc.contributor.authorComan, Irene
dc.contributor.authorComi, Giancarlo
dc.contributor.authorCorrado, Lucia
dc.contributor.authorCosemans, Leentje
dc.contributor.authorCournu-Rebeix, Isabelle
dc.contributor.authorCree, Bruce AC
dc.contributor.authorCusi, Daniele
dc.contributor.authorDamotte, Vincent
dc.contributor.authorDefer, Gilles
dc.contributor.authorDelgado, Silvia R
dc.contributor.authorDeloukas, Panos
dc.contributor.authordi Sapio, Alessia
dc.contributor.authorDilthey, Alexander T
dc.contributor.authorDonnelly, Peter
dc.contributor.authorDubois, Benedicte
dc.contributor.authorDuddy, Martin
dc.contributor.authorEdkins, Sarah
dc.contributor.authorElovaara, Irina
dc.contributor.authorEsposito, Federica
dc.contributor.authorEvangelou, Nikos
dc.contributor.authorFiddes, Barnaby
dc.contributor.authorField, Judith
dc.contributor.authorFranke, Andre
dc.contributor.authorFreeman, Colin
dc.contributor.authorFrohlich, Irene Y
dc.contributor.authorGalimberti, Daniela
dc.contributor.authorGieger, Christian
dc.contributor.authorGourraud, Pierre-Antoine
dc.contributor.authorGraetz, Christiane
dc.contributor.authorGraham, Andrew
dc.contributor.authorGrummel, Verena
dc.contributor.authorGuaschino, Clara
dc.contributor.authorHadjixenofontos, Athena
dc.contributor.authorHakonarson, Hakon
dc.contributor.authorHalfpenny, Christopher
dc.contributor.authorHall, Gillian
dc.contributor.authorHall, Per
dc.contributor.authorHamsten, Anders
dc.contributor.authorHarley, James
dc.contributor.authorHarrower, Timothy
dc.contributor.authorHawkins, Clive
dc.contributor.authorHellenthal, Garrett
dc.contributor.authorHillier, Charles
dc.contributor.authorHobart, Jeremy
dc.contributor.authorHoshi, Muni
dc.contributor.authorHunt, Sarah E
dc.contributor.authorJagodic, Maja
dc.contributor.authorJelcic, Ilijas
dc.contributor.authorJochim, Angela
dc.contributor.authorKendall, Brian
dc.contributor.authorKermode, Allan
dc.contributor.authorKilpatrick, Trevor
dc.contributor.authorKoivisto, Keijo
dc.contributor.authorKonidari, Ioanna
dc.contributor.authorKorn, Thomas
dc.contributor.authorKronsbein, Helena
dc.contributor.authorLangford, Cordelia
dc.contributor.authorLarsson, Malin
dc.contributor.authorLathrop, Mark
dc.contributor.authorLebrun-Frenay, Christine
dc.contributor.authorLechner-Scott, Jeannette
dc.contributor.authorLee, Michelle H
dc.contributor.authorLeone, Maurizio A
dc.contributor.authorLeppa, Virpi
dc.contributor.authorLiberatore, Giuseppe
dc.contributor.authorLie, Benedicte A
dc.contributor.authorLill, Christina M
dc.contributor.authorLinden, Magdalena
dc.contributor.authorLink, Jenny
dc.contributor.authorLuessi, Felix
dc.contributor.authorLycke, Jan
dc.contributor.authorMacciardi, Fabio
dc.contributor.authorMannisto, Satu
dc.contributor.authorManrique, Clara P
dc.contributor.authorMartin, Roland
dc.contributor.authorMartinelli, Vittorio
dc.contributor.authorMason, Deborah
dc.contributor.authorMazibrada, Gordon
dc.contributor.authorMcCabe, Cristin
dc.contributor.authorMero, Inger-Lise
dc.contributor.authorMescheriakova, Julia
dc.contributor.authorMoutsianas, Loukas
dc.contributor.authorMyhr, Kjell-Morten
dc.contributor.authorNagels, Guy
dc.contributor.authorNicholas, Richard
dc.contributor.authorNilsson, Petra
dc.contributor.authorPiehl, Fredrik
dc.contributor.authorPirinen, Matti
dc.contributor.authorPrice, Sian E
dc.contributor.authorQuach, Hong
dc.contributor.authorReunanen, Mauri
dc.contributor.authorRobberecht, Wim
dc.contributor.authorRobertson, Neil P
dc.contributor.authorRodegher, Mariaemma
dc.contributor.authorRog, David
dc.contributor.authorSalvetti, Marco
dc.contributor.authorSchnetz-Boutaud, Nathalie C
dc.contributor.authorSellebjerg, Finn
dc.contributor.authorSelter, Rebecca C
dc.contributor.authorSchaefer, Catherine
dc.contributor.authorShaunak, Sandip
dc.contributor.authorShen, Ling
dc.contributor.authorShields, Simon
dc.contributor.authorSiffrin, Volker
dc.contributor.authorSlee, Mark
dc.contributor.authorSorensen, Per Soelberg
dc.contributor.authorSorosina, Melissa
dc.contributor.authorSospedra, Mireia
dc.contributor.authorSpurkland, Anne
dc.contributor.authorStrange, Amy
dc.contributor.authorSundqvist, Emilie
dc.contributor.authorThijs, Vincent
dc.contributor.authorThorpe, John
dc.contributor.authorTicca, Anna
dc.contributor.authorTienari, Pentti
dc.contributor.authorvan Duijn, Cornelia
dc.contributor.authorVisser, Elizabeth M
dc.contributor.authorVucic, Steve
dc.contributor.authorWesterlind, Helga
dc.contributor.authorWiley, James S
dc.contributor.authorWilkins, Alastair
dc.contributor.authorWilson, James F
dc.contributor.authorWinkelmann, Juliane
dc.contributor.authorZajicek, John
dc.contributor.authorZindler, Eva
dc.contributor.authorHaines, Jonathan L
dc.contributor.authorPericak-Vance, Margaret A
dc.contributor.authorIvinson, Adrian J
dc.contributor.authorStewart, Graeme
dc.contributor.authorHafler, David
dc.contributor.authorHauser, Stephen L
dc.contributor.authorCompston, Alastair
dc.contributor.authorMcVean, Gil
dc.contributor.authorDe Jager, Philip
dc.contributor.authorSawcer, Stephen J
dc.contributor.authorMcCauley, Jacob L
dc.date.accessioned2018-07-31T03:47:34Z
dc.date.available2018-07-31T03:47:34Z
dc.date.issued2013
dc.identifier.issn1061-4036
dc.identifier.doi10.1038/ng.2770
dc.identifier.urihttp://hdl.handle.net/10072/57282
dc.description.abstractUsing the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 נ10-4). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 נ10-8), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1353
dc.relation.ispartofpageto1360
dc.relation.ispartofissue11
dc.relation.ispartofjournalNature Genetics
dc.relation.ispartofvolume45
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleAnalysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2013 Nature Publishing Group. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.date.issued2015-06-03T02:55:46Z
gro.hasfulltextFull Text
gro.griffith.authorBroadley, Simon
gro.griffith.authorButzkueven, Helmut


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