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  • Defining a substrate-binding model of a polysialyltransferase

    Author(s)
    Freiberger, Friedrich
    Boehm, Raphael
    Schwarzer, David
    Gerardy-Schahn, Rita
    Haselhorst, Thomas
    von Itzstein, Mark
    Griffith University Author(s)
    von Itzstein, Mark
    Haselhorst, Thomas E.
    Bohm, Raphael
    Year published
    2013
    Metadata
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    Abstract
    Highly disciplined transfers: Polysialyltransferases are important enzymes responsible for the biosynthesis of a-linked polysialic acids. We used a multidisciplinary approach, and propose the first substrate-binding model for a bacterial polysialyltransferase. Furthermore, we identify key amino acid residues involved in catalysis.Highly disciplined transfers: Polysialyltransferases are important enzymes responsible for the biosynthesis of a-linked polysialic acids. We used a multidisciplinary approach, and propose the first substrate-binding model for a bacterial polysialyltransferase. Furthermore, we identify key amino acid residues involved in catalysis.
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    Journal Title
    ChemBioChem
    Volume
    14
    Issue
    15
    DOI
    https://doi.org/10.1002/cbic.201300367
    Subject
    Medicinal and biomolecular chemistry
    Proteins and peptides
    Biochemistry and cell biology
    Enzymes
    Publication URI
    http://hdl.handle.net/10072/57323
    Collection
    • Journal articles

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