Defining a substrate-binding model of a polysialyltransferase
Author(s)
Freiberger, Friedrich
Boehm, Raphael
Schwarzer, David
Gerardy-Schahn, Rita
Haselhorst, Thomas
von Itzstein, Mark
Year published
2013
Metadata
Show full item recordAbstract
Highly disciplined transfers: Polysialyltransferases are important enzymes responsible for the biosynthesis of a-linked polysialic acids. We used a multidisciplinary approach, and propose the first substrate-binding model for a bacterial polysialyltransferase. Furthermore, we identify key amino acid residues involved in catalysis.Highly disciplined transfers: Polysialyltransferases are important enzymes responsible for the biosynthesis of a-linked polysialic acids. We used a multidisciplinary approach, and propose the first substrate-binding model for a bacterial polysialyltransferase. Furthermore, we identify key amino acid residues involved in catalysis.
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Journal Title
ChemBioChem
Volume
14
Issue
15
Subject
Medicinal and biomolecular chemistry
Proteins and peptides
Biochemistry and cell biology
Enzymes