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dc.contributor.authorUddin, SJ
dc.contributor.authorBettadapura, J
dc.contributor.authorGuillon, P
dc.contributor.authorGrice I, D
dc.contributor.authorMahalingam, S
dc.contributor.authorTiralongo, E
dc.date.accessioned2017-11-27T12:00:32Z
dc.date.available2017-11-27T12:00:32Z
dc.date.issued2013
dc.date.modified2014-03-27T04:35:22Z
dc.identifier.issn1948-5964
dc.identifier.doi10.4172/jaa.1000078
dc.identifier.urihttp://hdl.handle.net/10072/57380
dc.description.abstractBackground: Over the past century dengue (DENV2), chikungunya (CHIKV) and human parainfluenza (hPiV3) viruses have profoundly impacted on human morbidity, mortality and the economy worldwide. Current therapy options to treat infections of these viruses have severe limitations leading to a continued search for novel drug candidates. Acrostichum aureum L. (Pteridaceae) is a mangrove fern, that has been used as a traditional medicine in Bangladesh and other various countries for a variety of diseases including infection. Objectives: Isolation and structural elucidation of novel antiviral secondary metabolites from the methanol extract of the aerial parts of A. aureum. Materials and methods: The novel phthalate acid ester was isolated (HPLC) and structurally elucidated using 1D and 2D NMR, MS and other spectroscopic methods. The compound was tested for antiviral activity against DENV2 andhPiV3in Vero cells using the fluorescent focus (FFA) assay and against CHIKV virus in LLC-MK2 cells using the plaque-forming unit assay (PFU). The activity of the isolated compound was further compared with its known derivative. Results: In this study, we report on the isolation of a novel phthalic acid ester, 2''-(methoxycarbonyl)-5''- methylpentyl 2'-methylhexyl phthalate from the aerial parts of the Bangladeshi mangrove fern Acrostichumaureum and its in vitro antiviral activity. The novel phthalate showed antiviral activity against dengue virus, human parainfluenza virus and chikungunya. The most potent activity was recorded against hPiV3 (EC50 29.4 卩 and was slightly higher than the activity determined for the positive control BCX 2798 (EC50 44 卩. Cellulose acetate phthalate was also evaluated for antiviral activity against these viruses for the first time and was found to be inactive. Both compounds were found to be non-toxic against Vero and LLC-MK2 cells. Conclusion: This study shows that some selected phthalates have potent antiviral activity and should be further investigated as potential novel antiviral agents.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1172936 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.publisherOmics Publishing Group
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom139
dc.relation.ispartofpageto144
dc.relation.ispartofissue6
dc.relation.ispartofjournalJournal of Antivirals and Antiretrovirals
dc.relation.ispartofvolume5
dc.rights.retentionY
dc.subject.fieldofresearchBiologically active molecules
dc.subject.fieldofresearchNatural products and bioactive compounds
dc.subject.fieldofresearchcode340401
dc.subject.fieldofresearchcode340502
dc.titleIn-vitro Antiviral Activity of a Novel Phthalic Acid Ester Derivative Isolated from the Bangladeshi Mangrove Fern Acrostichumaureum
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0/
gro.facultyGriffith Health, School of Pharmacy
gro.rights.copyright© The Author(s) 2013. For information about this journal please refer to the publisher’s website or contact the authors. Articles are licensed under the terms of the Creative Commons Attribution 2.0 Generic (CC BY 2.0) license (http://creativecommons.org/licenses/by/2.0/) which permits unrestricted distribution and reproduction in any medium, providing that the work is properly cited.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorGrice, Darren D.
gro.griffith.authorTiralongo, Evelin
gro.griffith.authorGuillon, Patrice M.
gro.griffith.authorMahalingam, Suresh


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