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  • Lab-on-a-chip for rapid electrochemical detection of nerve agent Sarin

    Author(s)
    Tan, Hsih Yin
    Loke, Weng Keong
    Nam-Trung, Nguyen
    Tan, Swee Ngin
    Tay, Nam Beng
    Wang, Wei
    Ng, Sum Huan
    Griffith University Author(s)
    Nguyen, Nam-Trung
    Year published
    2014
    Metadata
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    Abstract
    his paper reports a lab-on-a-chip for the detection of Sarin nerve agent based on rapid electrochemical detection. The chemical warfare agent Sarin (C4H10FO2P, O-isopropyl methylphosphonofluoridate) is a highly toxic organophosphate that induces rapid respiratory depression, seizures and death within minutes of inhalation. As purified Sarin is colourless, odourless, water soluble and a easily disseminated nerve agent, it has been used as a weapon in terrorist or military attacks. To ascertain whether potable water supplies have been adulterated with this extremely potent poison, an inexpensive, sensitive and easy to use ...
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    his paper reports a lab-on-a-chip for the detection of Sarin nerve agent based on rapid electrochemical detection. The chemical warfare agent Sarin (C4H10FO2P, O-isopropyl methylphosphonofluoridate) is a highly toxic organophosphate that induces rapid respiratory depression, seizures and death within minutes of inhalation. As purified Sarin is colourless, odourless, water soluble and a easily disseminated nerve agent, it has been used as a weapon in terrorist or military attacks. To ascertain whether potable water supplies have been adulterated with this extremely potent poison, an inexpensive, sensitive and easy to use portable test kit would be of interest to first responders investigating such attacks. We report here an amperometric-based approach for detecting trace amounts of Sarin in water samples using a screen-printed electrode (SPE) integrated in a microfluidic chip. Enzymatic inhibition was obtained by exposing the immobilised biosensor in the microfluidic platform to Sarin in water samples. With the aid of cobalt phthalocyanine modified SPE, the device could detect Sarin at part-per-billion levels with concentration as low as 1 nM. The detection method reported here represents a significant improvement over the authors'previous optical-based detection method.
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    Journal Title
    Biomedical Microdevices
    DOI
    https://doi.org/10.1007/s10544-013-9830-4
    Subject
    Electroanalytical chemistry
    Biomedical engineering
    Materials engineering
    Engineering practice and education not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/57486
    Collection
    • Journal articles

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