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dc.contributor.authorTan, Hsih Yin
dc.contributor.authorLoke, Weng Keong
dc.contributor.authorNam-Trung, Nguyen
dc.contributor.authorTan, Swee Ngin
dc.contributor.authorTay, Nam Beng
dc.contributor.authorWang, Wei
dc.contributor.authorNg, Sum Huan
dc.contributor.editorM. Ferrari
dc.date.accessioned2017-05-03T16:14:49Z
dc.date.available2017-05-03T16:14:49Z
dc.date.issued2014
dc.date.modified2014-03-30T22:43:27Z
dc.identifier.issn1387-2176
dc.identifier.doi10.1007/s10544-013-9830-4
dc.identifier.urihttp://hdl.handle.net/10072/57486
dc.description.abstracthis paper reports a lab-on-a-chip for the detection of Sarin nerve agent based on rapid electrochemical detection. The chemical warfare agent Sarin (C4H10FO2P, O-isopropyl methylphosphonofluoridate) is a highly toxic organophosphate that induces rapid respiratory depression, seizures and death within minutes of inhalation. As purified Sarin is colourless, odourless, water soluble and a easily disseminated nerve agent, it has been used as a weapon in terrorist or military attacks. To ascertain whether potable water supplies have been adulterated with this extremely potent poison, an inexpensive, sensitive and easy to use portable test kit would be of interest to first responders investigating such attacks. We report here an amperometric-based approach for detecting trace amounts of Sarin in water samples using a screen-printed electrode (SPE) integrated in a microfluidic chip. Enzymatic inhibition was obtained by exposing the immobilised biosensor in the microfluidic platform to Sarin in water samples. With the aid of cobalt phthalocyanine modified SPE, the device could detect Sarin at part-per-billion levels with concentration as low as 1 nM. The detection method reported here represents a significant improvement over the authors'previous optical-based detection method.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto7
dc.relation.ispartofjournalBiomedical Microdevices
dc.rights.retentionY
dc.subject.fieldofresearchElectroanalytical chemistry
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchMaterials engineering
dc.subject.fieldofresearchEngineering practice and education not elsewhere classified
dc.subject.fieldofresearchcode340103
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode4016
dc.subject.fieldofresearchcode401099
dc.titleLab-on-a-chip for rapid electrochemical detection of nerve agent Sarin
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorNguyen, Nam-Trung


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