Chemical investigation of an antimalarial Chinese medicinal herb Picrorhiza scrophulariiflora

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Author(s)
Wang, Hongmin
Zhao, Weimin
Choomuenwai, Vanida
Andrews, Katherine T
Quinn, Ronald J
Feng, Yunjiang
Year published
2013
Metadata
Show full item recordAbstract
An antimalarial medicinal plant Picrorhiza scrophulariiflora was chemically investigated as part of our ongoing research in traditional chinese medicines (TCM). Mass directed fractionation of the active part of the crude extract led to the isolation of ten main components, three new compounds (1-3) and seven known compounds (4-10). Compound 10 inhibited the growth of the Plasmodium falciparum 3D7 malarial parasite line, with an IC50 value of 8.3 lM. This compound accounted for 95% of P. falciparum growth inhibitory activity in the crudAn antimalarial medicinal plant Picrorhiza scrophulariiflora was chemically investigated as part of our ongoing research in traditional chinese medicines (TCM). Mass directed fractionation of the active part of the crude extract led to the isolation of ten main components, three new compounds (1-3) and seven known compounds (4-10). Compound 10 inhibited the growth of the Plasmodium falciparum 3D7 malarial parasite line, with an IC50 value of 8.3 lM. This compound accounted for 95% of P. falciparum growth inhibitory activity in the crud
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Journal Title
Bioorganic & Medicinal Chemistry Letters
Volume
23
Issue
21
Copyright Statement
© 2013 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Medicinal and biomolecular chemistry
Medicinal and biomolecular chemistry not elsewhere classified
Organic chemistry
Pharmacology and pharmaceutical sciences