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  • Chemical investigation of an antimalarial Chinese medicinal herb Picrorhiza scrophulariiflora

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    92203_1.pdf (517.1Kb)
    Author(s)
    Wang, Hongmin
    Zhao, Weimin
    Choomuenwai, Vanida
    Andrews, Katherine T
    Quinn, Ronald J
    Feng, Yunjiang
    Griffith University Author(s)
    Quinn, Ronald J.
    Andrews, Katherine T.
    Feng, Yun J.
    Year published
    2013
    Metadata
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    Abstract
    An antimalarial medicinal plant Picrorhiza scrophulariiflora was chemically investigated as part of our ongoing research in traditional chinese medicines (TCM). Mass directed fractionation of the active part of the crude extract led to the isolation of ten main components, three new compounds (1-3) and seven known compounds (4-10). Compound 10 inhibited the growth of the Plasmodium falciparum 3D7 malarial parasite line, with an IC50 value of 8.3 lM. This compound accounted for 95% of P. falciparum growth inhibitory activity in the crudAn antimalarial medicinal plant Picrorhiza scrophulariiflora was chemically investigated as part of our ongoing research in traditional chinese medicines (TCM). Mass directed fractionation of the active part of the crude extract led to the isolation of ten main components, three new compounds (1-3) and seven known compounds (4-10). Compound 10 inhibited the growth of the Plasmodium falciparum 3D7 malarial parasite line, with an IC50 value of 8.3 lM. This compound accounted for 95% of P. falciparum growth inhibitory activity in the crud
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    Journal Title
    Bioorganic & Medicinal Chemistry Letters
    Volume
    23
    Issue
    21
    DOI
    https://doi.org/10.1016/j.bmcl.2013.08.077
    Copyright Statement
    © 2013 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Medicinal and biomolecular chemistry
    Medicinal and biomolecular chemistry not elsewhere classified
    Organic chemistry
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/57514
    Collection
    • Journal articles

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