Chemical investigation of an antimalarial Chinese medicinal herb Picrorhiza scrophulariiflora
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An antimalarial medicinal plant Picrorhiza scrophulariiflora was chemically investigated as part of our ongoing research in traditional chinese medicines (TCM). Mass directed fractionation of the active part of the crude extract led to the isolation of ten main components, three new compounds (1-3) and seven known compounds (4-10). Compound 10 inhibited the growth of the Plasmodium falciparum 3D7 malarial parasite line, with an IC50 value of 8.3 lM. This compound accounted for 95% of P. falciparum growth inhibitory activity in the crud
Bioorganic & Medicinal Chemistry Letters
© 2013 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Medicinal and Biomolecular Chemistry not elsewhere classified