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dc.contributor.authorM. Zalucki, Yaramah
dc.contributor.authorDhulipala, Vijaya
dc.contributor.authorM. Shafer, William
dc.date.accessioned2019-01-18T12:32:28Z
dc.date.available2019-01-18T12:32:28Z
dc.date.issued2012
dc.date.modified2014-05-22T22:15:42Z
dc.identifier.issn2150-7511
dc.identifier.doi10.1128/mBio.00446-12
dc.identifier.urihttp://hdl.handle.net/10072/57515
dc.description.abstractThis paper examines the folding mechanism of an individual ߭hairpin in the presence of other hairpins by using an off-lattice model of a small triple-stranded antiparallel ߭sheet protein, Pin1 WW domain. The turn zipper model and the hydrophobic collapse model originally developed for a single ߭hairpin in literature is confirmed to be useful in describing ߭hairpins in model Pin1 WW domain. We find that the mechanism for folding a specific hairpin is independent of whether it folds first or second, but the formation process are significantly dependent on temperature. More specifically, ߱-߲ hairpin folds via the turn zipper model at a low temperature and the hydrophobic collapse model at a high temperature, while the folding of ߲-߳ hairpin follows the turn zipper model at both temperatures. The change in folding mechanisms is interpreted by the interplay between contact stability (enthalpy) and loop lengths (entropy), the effect of which is temperature dependent.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent248641 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society for Microbiology
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome00446-12-1
dc.relation.ispartofpagetoe00446-12-7
dc.relation.ispartofissue6
dc.relation.ispartofjournalmBio
dc.relation.ispartofvolume3
dc.rights.retentionY
dc.subject.fieldofresearchMicrobial Genetics
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchcode060503
dc.subject.fieldofresearchcode0605
dc.titleDueling Regulatory Properties of a Transcriptional Activator (MtrA) and Repressor (MtrR) That Control Efflux Pump Gene Expression in Neisseria gonorrhoeae
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2012 American Society for Microbiology. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorZalucki, Yaramah


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