Natural Killer Cell Cytotoxic Activity: Measurement of the Apoptotic Inducing Mechanisms
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Natural Killer cell cytotoxic activity is vital for the clearance of viral and malignantly transformed cells. The aim of this study was to investigate the apoptotic inducing mechanisms of NK cells to propose an additional measurement for NK cell effector function. 19 healthy co ntrols (age=31ᷮ2 years) participated in this study. Flow cyto metric protocols assessed NK cell cytotoxic activity against tumour K562 cells, lytic proteins , degranulation and interferon gamma production. Perforin release was significantly correlated with cytotoxic activity (r=-0.46, p<0.05) and degranulation (r=- 0.60, p<0.05). These results suggest that perforin may be an additional measure for NK cell cytotoxic effector function.
Clinical and Experimental Medical Sciences
© The Author(s) 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Immunology not elsewhere classified