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dc.contributor.authorHuth, Teilah
dc.contributor.authorBrenu, Ekua
dc.contributor.authorAshton, Kevin J.
dc.contributor.authorStaines, Don R.
dc.contributor.authorMarshall-Gradisnik, Sonya
dc.date.accessioned2017-05-03T16:11:11Z
dc.date.available2017-05-03T16:11:11Z
dc.date.issued2013
dc.date.modified2014-03-31T23:14:24Z
dc.identifier.issn13147676
dc.identifier.urihttp://hdl.handle.net/10072/57531
dc.description.abstractNatural Killer cell cytotoxic activity is vital for the clearance of viral and malignantly transformed cells. The aim of this study was to investigate the apoptotic inducing mechanisms of NK cells to propose an additional measurement for NK cell effector function. 19 healthy co ntrols (age=31ᷮ2 years) participated in this study. Flow cyto metric protocols assessed NK cell cytotoxic activity against tumour K562 cells, lytic proteins , degranulation and interferon gamma production. Perforin release was significantly correlated with cytotoxic activity (r=-0.46, p<0.05) and degranulation (r=- 0.60, p<0.05). These results suggest that perforin may be an additional measure for NK cell cytotoxic effector function.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent193733 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherHikari
dc.publisher.placeBulgaria
dc.publisher.urihttp://www.m-hikari.com/cems/cems2013/cems5-8-2013/
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom373
dc.relation.ispartofpageto386
dc.relation.ispartofissue8
dc.relation.ispartofjournalClinical and Experimental Medical Sciences
dc.relation.ispartofvolume1
dc.rights.retentionY
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchcode110799
dc.titleNatural Killer Cell Cytotoxic Activity: Measurement of the Apoptotic Inducing Mechanisms
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/3.0/
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© The Author(s) 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorHuth, Teilah K.
gro.griffith.authorMarshall-Gradisnik, Sonya M.
gro.griffith.authorBrenu, Ekua


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    Contains articles published by Griffith authors in scholarly journals.

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