dc.contributor.author | Galvao, Daniel A | |
dc.contributor.author | Spry, Nigel | |
dc.contributor.author | Denham, James | |
dc.contributor.author | Taaffe, Dennis R | |
dc.contributor.author | Cormie, Prue | |
dc.contributor.author | Joseph, David | |
dc.contributor.author | Lamb, David S | |
dc.contributor.author | Chambers, Suzanne K | |
dc.contributor.author | Newton, Robert U | |
dc.date.accessioned | 2017-07-27T01:30:28Z | |
dc.date.available | 2017-07-27T01:30:28Z | |
dc.date.issued | 2014 | |
dc.date.modified | 2014-03-31T23:22:18Z | |
dc.identifier.issn | 0302-2838 | |
dc.identifier.doi | 10.1016/j.eururo.2013.09.041 | |
dc.identifier.uri | http://hdl.handle.net/10072/57546 | |
dc.description.abstract | Background: Long-term prostate cancer (PCa) survivors are at increased risk for comorbidities and physical deconditioning. Objective: To determine the effectiveness of a year-long randomised controlled trial of exercise training in PCa survivors >5 yr postdiagnosis on physical functioning. Design, setting, and participants: Between 2010 and 2011, 100 long-term PCa survivors from Trans- Tasman Radiation Oncology Group 03.04 Randomised Androgen Deprivation and Radiotherapy previously treated with androgen-deprivation therapy and radiation therapy were randomly assigned to 6 mo of supervised exercise followed by 6 mo of a home-based maintenance programme (n = 50) or printed educational material about physical activity (n = 50) for 12 mo across 13 university-affiliated exercise clinics in Australia and New Zealand. Intervention: Supervised resistance and aerobic exercise or printed educational material about physical activity. Outcome measurements and statistical analysis: The primary end point was a 400-m walk as a measure of cardiovascular fitness. Secondary end points were physical function, patient-reported outcomes, muscle strength, body composition, and biomarkers. Analysis of covariance was used to compare outcomes for groups at 6 and 12 mo adjusted for baseline values. Results and limitations: Participants undergoing supervised exercise showed improvement in cardiorespiratory fitness performance at 6 mo ( 19 s [p = 0.029]) and 12 mo ( 13 s [p = 0.028]) and better lower-body physical function across the 12-mo period ( p < 0.01). Supervised exercise also improved self-reported physical functioning at 6 ( p = .006) and 12 mo ( p = 0.002), appendicular skeletal muscle at 6 mo ( p = 0.019), and objective measures of muscle strength at 6 and 12 mo ( p < 0.050). Limitations included the restricted number of participants undertaking body composition assessment, no blinding to group assignment for physical functioning measures, and inclusion of well-functioning individuals. Conclusions: Supervised exercise training in long-term PCa survivors is more effective than physical activity educational material for increasing cardiorespiratory fitness, physical function, muscle strength, and self-reported physical functioning at 6 mo. Importantly, these benefits were maintained in the long term with a home-based programme with follow-up at 12 mo. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | Netherlands | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 856 | |
dc.relation.ispartofpageto | 864 | |
dc.relation.ispartofissue | 5 | |
dc.relation.ispartofjournal | European Urology | |
dc.relation.ispartofvolume | 65 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Exercise physiology | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 420702 | |
dc.title | A multicentre year-long randomised controlled trial of exercise training targeting physical functioning in men with prostate cancer previously treated with Androgen Suppression and Radiation from TROG 03.04 RADAR | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2013 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Chambers, Suzanne K. | |