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  • Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene

    Author(s)
    Schroder, W
    Cloonan, N
    Bushell, G
    Sculley, T
    Griffith University Author(s)
    Bushell, Gillian R.
    Schroder, Wayne
    Cloonan, Nicole
    Year published
    2004
    Metadata
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    Abstract
    Limited but significant sequence similarity has been observed between an uncharacterized human protein, SIN1, and the S. pombe SIN1, Dictyostelium RIP3 and S. cerevisiae AVO1 proteins. The human Sin1 gene has been automatically predicted (MAPKAP1; GenBank accession number NM_024117); however, this sequence appears to be incomplete. In this study, we have cloned and characterized the full-length human Sin1 mRNA and identified a highly conserved domain that defines the family of SIN1 orthologues, members of which are widely distributed in the fungal and metazoan kingdoms. We demonstrate that Sin1 transcripts can use alternative ...
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    Limited but significant sequence similarity has been observed between an uncharacterized human protein, SIN1, and the S. pombe SIN1, Dictyostelium RIP3 and S. cerevisiae AVO1 proteins. The human Sin1 gene has been automatically predicted (MAPKAP1; GenBank accession number NM_024117); however, this sequence appears to be incomplete. In this study, we have cloned and characterized the full-length human Sin1 mRNA and identified a highly conserved domain that defines the family of SIN1 orthologues, members of which are widely distributed in the fungal and metazoan kingdoms. We demonstrate that Sin1 transcripts can use alternative polyadenylation signals and describe a number of Sin1 splice variants that potentially encode functionally different isoforms.
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    Journal Title
    Gene
    Volume
    339
    Publisher URI
    http://www.elsevier.com/wps/find/journaldescription.cws_home/506033/description#description
    DOI
    https://doi.org/10.1016/j.gene.2004.07.001
    Copyright Statement
    © 2004 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.
    Subject
    Genetics
    Physiology
    Medical Microbiology
    Publication URI
    http://hdl.handle.net/10072/5759
    Collection
    • Journal articles

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