Show simple item record

dc.contributor.authorSchroder, Wayneen_US
dc.contributor.authorCloonan, Nicoleen_US
dc.contributor.authorBushell, Gillianen_US
dc.contributor.authorSculley, Tomen_US
dc.date.accessioned2017-05-03T11:32:22Z
dc.date.available2017-05-03T11:32:22Z
dc.date.issued2004en_US
dc.date.modified2009-12-05T05:16:51Z
dc.identifier.issn03781119en_US
dc.identifier.doi10.1016/j.gene.2004.07.001en_AU
dc.identifier.urihttp://hdl.handle.net/10072/5759
dc.description.abstractLimited but significant sequence similarity has been observed between an uncharacterized human protein, SIN1, and the S. pombe SIN1, Dictyostelium RIP3 and S. cerevisiae AVO1 proteins. The human Sin1 gene has been automatically predicted (MAPKAP1; GenBank accession number NM_024117); however, this sequence appears to be incomplete. In this study, we have cloned and characterized the full-length human Sin1 mRNA and identified a highly conserved domain that defines the family of SIN1 orthologues, members of which are widely distributed in the fungal and metazoan kingdoms. We demonstrate that Sin1 transcripts can use alternative polyadenylation signals and describe a number of Sin1 splice variants that potentially encode functionally different isoforms.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeAmsterdam, Hollanden_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/506033/description#descriptionen_AU
dc.relation.ispartofpagefrom17en_US
dc.relation.ispartofpageto23en_US
dc.relation.ispartofjournalGeneen_US
dc.relation.ispartofvolume339en_US
dc.subject.fieldofresearchcode270201en_US
dc.titleAlternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 geneen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2004 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.en_AU
gro.date.issued2004
gro.hasfulltextNo Full Text


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record