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dc.contributor.authorWest, Nicholas P
dc.contributor.authorChristophersen, Claus T
dc.contributor.authorPyne, David B
dc.contributor.authorCripps, Allan W
dc.contributor.authorConlon, Michael A
dc.contributor.authorTopping, David L
dc.contributor.authorKang, Seungha
dc.contributor.authorMcSweeney, Chris S
dc.contributor.authorFricker, Peter A
dc.contributor.authorAguirre, Daniel
dc.contributor.authorClarke, Julie M
dc.date.accessioned2017-05-03T14:31:25Z
dc.date.available2017-05-03T14:31:25Z
dc.date.issued2013
dc.date.modified2014-04-02T04:46:57Z
dc.identifier.issn1077-5552
dc.identifier.urihttp://hdl.handle.net/10072/57650
dc.description.abstractBACKGROUND: Butyrate delivery to the large bowel may positively modulate commensal microbiota and enhance immunity. OBJECTIVE: To determine the effects of increasing large bowel butyrate concentration through ingestion of butyrylated high amylose maize starch (HAMSB) on faecal biochemistry and microbiota, and markers of immunity in healthy active individuals. DESIGN: Male and female volunteers were assigned randomly to consume either two doses of 20 g HAMSB (n = 23; age 37.9 +/- 7.8 y; mean +/- SD) or a low amylose maize starch (LAMS) (n = 18; age 36.9 = 9.5 y) twice daily for 28 days. Samples were collected on days 0, 10 and 28 for assessment of faecal bacterial groups, faecal biochemistry, serum cytokines and salivary antimicrobial proteins. RESULTS: HAMSB led to relative increases in faecal free (45%; 12-86%; mean; 90% confidence interval; P = 0.02), bound (950%; 563-1564%; P < 0.01) and total butyrate (260%; 174-373%; P < 0.01) and faecal propionate (41%; 12-77%; P = 0.02) from day 0 to day 28 compared to LAMS. HAMSB was also associated with a relative 1.6-fold (1.2- to 2.0-fold; P < 0.01) and 2.5-fold (1.4- to 4.4-fold; P = 0.01) increase in plasma IL-10 and TNF-alpha but did not alter other indices of immunity. There were relative greater increases in faecal P. distasonis (81-fold (28- to 237-fold; P < 0.01) and F. prausnitzii (5.1-fold (2.1- to 12-fold; P < 0.01) in the HAMSB group. CONCLUSIONS: HAMSB supplementation in healthy active individuals promotes the growth of bacteria that may improve bowel health and has only limited effects on plasma cytokines.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent307567 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherVerein zur Foerderung der Sportmedizin
dc.publisher.placeGermany
dc.publisher.urihttp://www.isei.dk/index.php?pageid=3
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom102
dc.relation.ispartofpageto119
dc.relation.ispartofjournalExercise Immunology Review
dc.relation.ispartofvolume19
dc.rights.retentionY
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode320499
dc.titleButyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Allied Health Sciences
gro.rights.copyright© 2013 Hinnak Northoff. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorCripps, Allan W.
gro.griffith.authorWest, Nic P.
gro.griffith.authorPyne, David B.


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