• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation

    Thumbnail
    View/Open
    92773_1.pdf (393.3Kb)
    Author(s)
    Shigdar, Sarah
    Macdonald, Joanna
    O'Connor, Michael
    Wang, Tao
    Xiang, Dongxi
    Al Shamaileh, Hadi
    Qiao, Liang
    Wei, Ming
    Zhou, Shu-Feng
    Zhu, Yimin
    Kong, Lingxue
    Bhattacharya, Santanu
    Li, ChunGuang
    Duan, Wei
    Griffith University Author(s)
    Wei, Ming Q.
    Year published
    2013
    Metadata
    Show full item record
    Abstract
    Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.
    View less >
    Journal Title
    Sensors
    Volume
    13
    DOI
    https://doi.org/10.3390/s131013624
    Copyright Statement
    © 2013 MDPI (http://www.mdpi.com). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Analytical chemistry
    Ecology
    Distributed computing and systems software
    Publication URI
    http://hdl.handle.net/10072/57742
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander