Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation

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Author(s)
Shigdar, Sarah
Macdonald, Joanna
O'Connor, Michael
Wang, Tao
Xiang, Dongxi
Al Shamaileh, Hadi
Qiao, Liang
Wei, Ming
Zhou, Shu-Feng
Zhu, Yimin
Kong, Lingxue
Bhattacharya, Santanu
Li, ChunGuang
Duan, Wei
Griffith University Author(s)
Year published
2013
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Abstract
Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.
Journal Title
Sensors
Volume
13
DOI
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© 2013 MDPI (http://www.mdpi.com). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Medical and Health Sciences not elsewhere classified
Analytical Chemistry
Distributed Computing
Electrical and Electronic Engineering
Environmental Science and Management
Ecology
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