Aptamers as Theranostic Agents: Modifications, Serum   Stability and Functionalisation

Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.

Journal Title

Sensors

Volume

DOI

https://doi.org/10.3390/s131013624

Copyright Statement

© 2013 MDPI (http://www.mdpi.com). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.

Subject

Medical and Health Sciences not elsewhere classified

Publication URI

http://hdl.handle.net/10072/57742

Collection

Journal articles