Show simple item record

dc.contributor.authorHorne-Debets, Joshua M
dc.contributor.authorFaleiro, Rebecca
dc.contributor.authorKarunarathne, Deshapriya S
dc.contributor.authorLiu, Xue Q
dc.contributor.authorLineburg, Katie E
dc.contributor.authorPoh, Chek Meng
dc.contributor.authorGrotenbreg, Gijsbert M
dc.contributor.authorHill, Geoffrey R
dc.contributor.authorMacDonald, Kelli PA
dc.contributor.authorGood, Michael F
dc.contributor.authorRenia, Laurent
dc.contributor.authorAhmed, Rafi
dc.contributor.authorSharpe, Arlene H
dc.contributor.authorWykes, Michelle N
dc.date.accessioned2017-05-03T15:04:56Z
dc.date.available2017-05-03T15:04:56Z
dc.date.issued2013
dc.identifier.issn2211-1247
dc.identifier.doi10.1016/j.celrep.2013.11.002
dc.identifier.urihttp://hdl.handle.net/10072/57752
dc.description.abstractMalaria is a highly prevalent disease caused by infection by Plasmodium spp., which infect hepatocytes and erythrocytes. Blood-stage infections cause devastating symptoms and can persist for years. Antibodies and CD4+ T cells are thought to protect against blood-stage infections. However, there has been considerable difficulty in developing an efficacious malaria vaccine, highlighting our incomplete understanding of immunity against this disease. Here, we used an experimental rodent malaria model to show that PD-1 mediates up to a 95% reduction in numbers and functional capacity of parasite-specific CD8+ T cells. Furthermore, in contrast to widely held views, parasite-specific CD8+ T cells are required to control both acute and chronic blood-stage disease even when parasite-specific antibodies and CD4+ T cells are present. Our findings provide a molecular explanation for chronic malaria that will be relevant to future malaria-vaccine design and may need consideration when vaccine development for other infections is problematic.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent2308250 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1204
dc.relation.ispartofpageto1213
dc.relation.ispartofissue5
dc.relation.ispartofjournalCell Reports
dc.relation.ispartofvolume5
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchBacteriology
dc.subject.fieldofresearchApplied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode310701
dc.subject.fieldofresearchcode320402
dc.subject.fieldofresearchcode3208
dc.titlePD-1 Dependent Exhaustion of CD8+ T Cells Drives Chronic Malaria
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/3.0/
gro.rights.copyright© 2013 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License (http://creativecommons.org/licenses/by-nc-nd/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.date.issued2015-03-20T04:34:07Z
gro.hasfulltextFull Text
gro.griffith.authorGood, Michael F.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record