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  • Self-adjuvanting Polymer-peptide Conjugates as Therapeutic Vaccine Candidates against Cervical Cancer

    Author(s)
    Liu, Tzu-Yu
    Hussein, Waleed M
    Jia, Zhongfan
    Ziora, Zyta M
    McMillan, Nigel AJ
    Monteiro, Michael J
    Toth, Istvan
    Skwarczynski, Mariusz
    Griffith University Author(s)
    McMillan, Nigel
    Monteiro, Michael J.
    Year published
    2013
    Metadata
    Show full item record
    Abstract
    Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.
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    Journal Title
    Biomacromolecules
    Volume
    14
    Issue
    8
    DOI
    https://doi.org/10.1021/bm400626w
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Cellular Immunology
    Chemical Sciences
    Biological Sciences
    Engineering
    Publication URI
    http://hdl.handle.net/10072/57761
    Collection
    • Journal articles

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