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dc.contributor.authorZhang, Li
dc.contributor.authorKeogh, Samantha
dc.contributor.authorRickard, Claire M
dc.date.accessioned2017-05-03T15:51:19Z
dc.date.available2017-05-03T15:51:19Z
dc.date.issued2013
dc.date.modified2014-04-03T04:00:47Z
dc.identifier.issn1178-2013
dc.identifier.doi10.2147/IJN.S50312
dc.identifier.urihttp://hdl.handle.net/10072/57799
dc.description.abstractIntravascular catheter-related infections are still a major problem in health care and are associated with significant morbidity, mortality, and additional cost. The formation of microbial biofilm on catheters makes these infections particularly complicated, as microbial cells that detach from the biofilm can lead to infection, and because these microorganisms are highly resistant to many antimicrobial agents; thus, catheter removal is often required to successfully treat infection. To reduce the risks of catheter-related infections, many strategies have been applied, such as improvements in aseptic insertion and post-insertion care practices, implantation techniques, and antibiotic coated or impregnated materials. However, despite significant advances in using these methods, it has not been possible to completely eradicate biofilm infections. Currently, nanotechnology approaches seem to be among the most promising for preventing biofilm formation and resultant catheter-related bloodstream infection (especially with multi-resistant bacterial strains). In this review, current knowledge about catheter technology and design, the mechanisms of catheter-related bloodstream infection, and the insertion and care practices performed by medical staff, are discussed, along with novel, achievable approaches to infection prevention, based on nanotechnology.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1095239 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.publisherDove Medical Press
dc.publisher.placeNew Zealand
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom4453
dc.relation.ispartofpageto4466
dc.relation.ispartofjournalInternational Journal of Nanomedicine
dc.relation.ispartofvolume8
dc.rights.retentionY
dc.subject.fieldofresearchClinical Nursing: Secondary (Acute Care)
dc.subject.fieldofresearchNanotechnology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode111003
dc.subject.fieldofresearchcode1007
dc.subject.fieldofresearchcode1115
dc.titleReducing the risk of infection associated with vascular access devices through nanotechnology: a perspective
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Nursing and Midwifery
gro.rights.copyright© 2013 Zhang et al, publisher and licencee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorZhang, Li
gro.griffith.authorRickard, Claire
gro.griffith.authorKeogh, Samantha J.


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