Identification of Early Cellular Immune Factors Regulating Growth of Malaria Parasites in Humans
Author(s)
F. Good, Michael
Griffith University Author(s)
Year published
2005
Metadata
Show full item recordAbstract
In many host-parasite systems, regulatory T cells (CD4+, CD25+, FOXP3+) have been shown to modulate cellular immunity and pathology. In this issue of Immunity, Walther et al. have now shown that following experimental malaria infection of human volunteers, enhanced TGF-ߠand T reg responses are associated with a faster parasite growth rate. The study demonstrates that regulation of cellular immunity must be addressed if we are to develop successful interventions.In many host-parasite systems, regulatory T cells (CD4+, CD25+, FOXP3+) have been shown to modulate cellular immunity and pathology. In this issue of Immunity, Walther et al. have now shown that following experimental malaria infection of human volunteers, enhanced TGF-ߠand T reg responses are associated with a faster parasite growth rate. The study demonstrates that regulation of cellular immunity must be addressed if we are to develop successful interventions.
View less >
View less >
Journal Title
Immunity
Volume
23
Issue
3
Subject
Immunology not elsewhere classified
Immunology