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  • Serial high resolution 3D–MRI after aortic banding in mice: band internalization is a source of variability in the hypertrophic response

    Author(s)
    A. Lygate, Craig
    E. Schneider, Jürgen
    Hulbert, Karen
    Hove, Michiel ten
    M. Sebag-Montefiore, Liam
    J. Cassidy, Paul
    Clarke, Kieran
    Neubauer, Stefan
    Griffith University Author(s)
    Cassidy, Paul
    Year published
    2006
    Metadata
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    Abstract
    Transverse aortic constriction (TAC) is used as a model of left ventricular hypertrophy and failure; however, there is extensive variability in the hypertrophic response. In 43 mice that underwent TAC with a 7-0 polypropylene suture, 13 were identified by echocardiography with initial LV hypertrophy that halted or regressed over time. Post-mortem examination on 7 of these mice found the constricting band to be intact, but partially internalized into the aortic lumen, allowing blood flow around the stenosis. To confirm this prospectively in vivo we then followed 12 mice after TAC for 6 weeks, using a new high resolution ...
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    Transverse aortic constriction (TAC) is used as a model of left ventricular hypertrophy and failure; however, there is extensive variability in the hypertrophic response. In 43 mice that underwent TAC with a 7-0 polypropylene suture, 13 were identified by echocardiography with initial LV hypertrophy that halted or regressed over time. Post-mortem examination on 7 of these mice found the constricting band to be intact, but partially internalized into the aortic lumen, allowing blood flow around the stenosis. To confirm this prospectively in vivo we then followed 12 mice after TAC for 6 weeks, using a new high resolution 3D-MRI method to measure minimal aortic arch cross-sectional area (CSA). Three of the 12 mice developed a significantly increased aortic CSA (0.31 ᠰ.15 on day 2 vs. 1.11 ᠰ.29 mm2 on day 42; P < 0.05), which was independently confirmed by dissection. These mice had internalized part of the band within the aortic lumen and, by week 6, showed significantly less LV hypertrophy and better systolic function. Nine of the 12 mice showed no change in aortic CSA. Band internalization could be prevented when two banding sutures were placed side-by-side (n = 10). This is the first observation that a significant subset of animals following TAC bypass the stenosis resulting in partial regression of hypertrophy.
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    Journal Title
    Basic Research in Cardiology
    Volume
    101
    Issue
    1
    DOI
    https://doi.org/10.1007/s00395-005-0546-3
    Subject
    Medical Physics
    Cardiorespiratory Medicine and Haematology
    Publication URI
    http://hdl.handle.net/10072/58098
    Collection
    • Journal articles

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