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dc.contributor.authorHargrave, M
dc.contributor.authorKarunaratne, A
dc.contributor.authorCox, L
dc.contributor.authorWood, S
dc.contributor.authorKoopman, P
dc.contributor.authorYamada, T
dc.date.accessioned2006-07-25
dc.date.accessioned2014-04-10T04:55:01Z
dc.date.accessioned2017-03-02T00:11:41Z
dc.date.available2017-03-02T00:11:41Z
dc.date.issued2000
dc.date.modified2014-04-10T04:55:01Z
dc.identifier.issn0012-1606
dc.identifier.doi10.1006/dbio.1999.9581
dc.identifier.urihttp://hdl.handle.net/10072/58163
dc.description.abstractCell-type diversity along the dorsoventral axis of the developing neural tube is influenced by factors secreted by groups of cells at the dorsal and ventral midline. Upon reception of these signals, precursor cells express specific sets of transcription factors which, in turn, play critical roles in cell-type specification. Here we report the cloning and characterization of Sox14, a novel and highly conserved member of the Sry-related Sox transcription factor gene family, in mouse and chick. Sox14 expression is restricted to a limited population of neurons in the developing brain and spinal cord of both species. Sox14 marks a subset of interneurons at a defined dorsoventral position adjacent to ventral motor neurons in the spinal cord. In vivo grafting of chick notochord tissue to ectopic positions adjacent to the developing spinal cord altered the expression domain of Sox14. Furthermore, expression of Sox14 in spinal cord explants was found to be regulated by Sonic hedgehog in a dose-dependent manner. These data implicate a novel class of transcription factors in dorsoventral cell-type specification in the spinal cord. Copyright 2000 Academic Press.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.publisherElsevier B.V.
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom142
dc.relation.ispartofpageto153
dc.relation.ispartofissue1
dc.relation.ispartofjournalDevelopmental Biology
dc.relation.ispartofvolume219
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleThe HMG box transcription factor gene Sox14 marks a novel subset of ventral interneurons and is regulated by sonic hedgehog.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyOther
gro.date.issued2000
gro.hasfulltextNo Full Text
gro.griffith.authorKarunaratne, Asanka M.
gro.griffith.authorWood, Stephen A.


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