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dc.contributor.authorWhite, H
dc.contributor.authorVenkatesh, B
dc.contributor.authorJones, M
dc.contributor.authorWorrall, S
dc.contributor.authorChuah, T
dc.contributor.authorOrdonez, J
dc.date.accessioned2017-05-03T14:21:16Z
dc.date.available2017-05-03T14:21:16Z
dc.date.issued2013
dc.date.modified2014-04-11T05:13:00Z
dc.identifier.issn0342-4642
dc.identifier.doi10.1007/s00134-012-2790-y
dc.identifier.urihttp://hdl.handle.net/10072/58267
dc.description.abstractPurpose Although glucose is the main source of energy for the human brain, ketones play an important role during starvation or injury. The purpose of our study was to investigate the metabolic effects of a novel hypertonic sodium ketone solution in normal animals. Methods Adult Sprague-Dawley rats (420-570 g) were divided into three groups of five, one control and two study arms. The control group received an intravenous infusion of 3 % NaCl at 5 ml/kg/h. The animals in the two study arms were assigned to receive one of the two formulations of ketone solutions, containing hypertonic saline with 40 and 120 mmol/l beta-hydroxybutyrate, respectively. This was infused for 6 h and then the animal was euthanized and brains removed and frozen. Results Both blood and cerebrospinal fluid (CSF) levels of beta-hydroxybutyrate (BHB) demonstrated strong evidence of a change over time (p < 0.0001). There was also strong evidence of a difference between groups (p < 0.0001). Multiple comparisons showed all these means were statistically different (p < 0.05). Measurement of BHB levels in brain tissue found strong evidence of a difference between groups (p < 0.0001) with control: 0.15 mmol/l (0.01), BHB 40: 0.19 mmol/l (0.01), and BHB 120: 0.28 mmol/l (0.01). Multiple comparisons showed all these means were statistically different (p < 0.05). There were no differences over time (p = 0.31) or between groups (p = 0.33) or an interaction between groups and time (p = 0.47) for base excess. Conclusion The IV infusions of hypertonic saline/BHB are feasible and lead to increased plasma, CSF and brain levels of BHB without significant acid/base effects.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom727
dc.relation.ispartofpageto733
dc.relation.ispartofissue4
dc.relation.ispartofjournalIntensive Care Medicine
dc.relation.ispartofvolume39
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleEffect of a hypertonic balanced ketone solution on plasma, CSF and brain beta-hydroxybutyrate levels and acid-base status
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medicine
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorWhite, Hayden T.


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