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dc.contributor.authorYarom, Noam
dc.contributor.authorAriyawardana, Sinhe
dc.contributor.authorHovan, Allan
dc.contributor.authorBarasch, Andrei
dc.contributor.authorJarvis, Virginia
dc.contributor.authorJensen, Siri Beier
dc.contributor.authorZadik, Yehuda
dc.contributor.authorElad, Sharon
dc.contributor.authorBowen, Joanne
dc.contributor.authorV. Lalla, Rajesh
dc.date.accessioned2017-05-03T12:43:18Z
dc.date.available2017-05-03T12:43:18Z
dc.date.issued2013
dc.date.modified2014-04-11T05:37:13Z
dc.identifier.issn0941-4355
dc.identifier.doi10.1007/s00520-013-1869-5
dc.identifier.urihttp://hdl.handle.net/10072/58311
dc.description.abstractPurpose The aim of this study was to review the available literature and define clinical practice guidelines for the use of natural agents for the prevention and treatment of oral mucositis. Methods A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology. The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guideline possible. Results A total of 49 papers across 15 interventions were examined. A new suggestion was developed in favor of systemic zinc supplements administered orally in the prevention of oral mucositis in oral cancer patients receiving radiation therapy or chemoradiation (Level III evidence). A recommendation was made against the use of intravenous glutamine for the prevention of oral mucositis in patients receiving high-dose chemotherapy prior to hematopoietic stem cell transplant (Level II evidence). No guideline was possible for any other agent, due to inadequate and/or conflicting evidence. Conclusions Of the various natural agents reviewed here, the available evidence supported a guideline only for two agents: a suggestion in favor of zinc and a recommendation against glutamine, in the treatment settings listed above. Well-designed studies of other natural agents are warranted.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom3209
dc.relation.ispartofpageto3221
dc.relation.ispartofissue11
dc.relation.ispartofjournalSupportive Care in Cancer
dc.relation.ispartofvolume21
dc.rights.retentionY
dc.subject.fieldofresearchCancer Therapy (excl. Chemotherapy and Radiation Therapy)
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchPsychology and Cognitive Sciences
dc.subject.fieldofresearchcode111204
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode17
dc.titleSystematic review of natural agents for the management of oral mucositis in cancer patients
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorAriyawardana, Sinhe


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