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  • Vaccine-induced immunity to malaria parasites and the need for novel strategies

    Author(s)
    F. Good, Michael
    Griffith University Author(s)
    Good, Michael F.
    Year published
    2005
    Metadata
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    Abstract
    History shows that vaccines are most easily developed for those organisms that induce natural immunity after a single infection. For malaria, partial antiparasite immunity develops only after several years of endemic exposure. Evidence suggests that this inefficient induction of immunity is partly a result of antigenic polymorphism, poor immunogenicity of individual antigens, the ability of the parasite to interfere with the development of immune responses and to cause apoptosis of effector and memory T and B cells, and the interaction of maternal and neonatal immunity. Vaccine strategies that are likely to be ultimately ...
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    History shows that vaccines are most easily developed for those organisms that induce natural immunity after a single infection. For malaria, partial antiparasite immunity develops only after several years of endemic exposure. Evidence suggests that this inefficient induction of immunity is partly a result of antigenic polymorphism, poor immunogenicity of individual antigens, the ability of the parasite to interfere with the development of immune responses and to cause apoptosis of effector and memory T and B cells, and the interaction of maternal and neonatal immunity. Vaccine strategies that are likely to be ultimately successful are those that combine many antigens to induce a maximal response to protective determinants that might not be normally recognized following normal infection of naive individuals. Whole organismal approaches and the use of ultra-low doses of antigens have shown success in human and animal studies by inducing enhanced immune responses to multiple antigens. These, and related hypervalent subunit approaches, could lead to a viable vaccine.
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    Journal Title
    Trends in Parasitology
    Volume
    21
    Issue
    1
    DOI
    https://doi.org/10.1016/j.pt.2004.10.006
    Subject
    Medical Microbiology not elsewhere classified
    Biological Sciences
    Agricultural and Veterinary Sciences
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/58346
    Collection
    • Journal articles

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