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dc.contributor.authorF. Good, Michael
dc.date.accessioned2017-05-03T14:53:36Z
dc.date.available2017-05-03T14:53:36Z
dc.date.issued2005
dc.date.modified2014-04-14T23:19:11Z
dc.identifier.issn14714906
dc.identifier.doi10.1016/j.it.2005.04.005
dc.identifier.urihttp://hdl.handle.net/10072/58348
dc.description.abstractA genetically modified malaria sporozoite might breathe new life into the traditional approach to vaccine development, that of using whole organisms. Mueller and colleagues recently knocked out a gene, UIS3, from the rodent parasite, Plasmodium berghei, and demonstrated that the sporozoite forms could not develop beyond the stage of the life cycle in the liver (thus not giving rise to clinical disease, which is associated with blood infection) but could induce protection against subsequent challenge with genetically intact sporozoites. UIS3(K) sporozoites or irradiated sporozoites might find success where subunit approaches are struggling.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom295
dc.relation.ispartofpageto297
dc.relation.ispartofissue6
dc.relation.ispartofjournalTrends in Immunology
dc.relation.ispartofvolume26
dc.rights.retentionY
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode110799
dc.subject.fieldofresearchcode1107
dc.titleGenetically modified Plasmodium highlights the potential of whole parasite vaccine strategies
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.


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