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  • Ross River virus: Molecular and cellular aspects of disease pathogenesis

    Author(s)
    Rulli, Nestor E.
    Suhrbier, Andreas
    Hueston, Linda
    Heise, Mark T.
    Tupanceska, Daniela
    Zaid, Ali
    Wilmes, Anja
    Gilmore, Kerry
    Lidbury, Brett A.
    Mahalingam, Surendran
    Griffith University Author(s)
    Rulli, Nestor
    Zaid, Ali
    Mahalingam, Suresh
    Year published
    2005
    Metadata
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    Abstract
    Ross River virus (RRV) is a mosquito-borne alphavirus indigenous to Australia and the Western Pacific region and is responsible for several thousand cases of human RRV disease (RRVD) per annum. The disease primarily involves polyarthritis/arthralgia, with many patients also presenting with rash, myalgia, fever, and/or lethargy. The symptoms can be debilitating at onset, but they usually resolve within 3-6 months. Recent insights into the RRV-host relationship, associated pathology, and molecular biology of infection have generated a number of potential avenues for improved treatment. Although vaccine development has been ...
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    Ross River virus (RRV) is a mosquito-borne alphavirus indigenous to Australia and the Western Pacific region and is responsible for several thousand cases of human RRV disease (RRVD) per annum. The disease primarily involves polyarthritis/arthralgia, with many patients also presenting with rash, myalgia, fever, and/or lethargy. The symptoms can be debilitating at onset, but they usually resolve within 3-6 months. Recent insights into the RRV-host relationship, associated pathology, and molecular biology of infection have generated a number of potential avenues for improved treatment. Although vaccine development has been proposed, the small market size and potential for antibody-dependent enhancement (ADE) of disease make this approach unattractive. Recent insights into the molecular basis of RRV-ADE and the virus's ability to manipulate host inflammatory and immune responses create potential new opportunities for therapeutic invention. Such interventions should overcome virus-induced dysregulation of protective host responses to promote viral clearance and/or ameliorate inflammatory immunopathology.
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    Journal Title
    Pharmacology & Therapeutics
    Volume
    107
    Issue
    3
    DOI
    https://doi.org/10.1016/j.pharmthera.2005.03.006
    Subject
    Medical Virology
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/58387
    Collection
    • Journal articles

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