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dc.contributor.authorRulli, Nestor E.
dc.contributor.authorSuhrbier, Andreas
dc.contributor.authorHueston, Linda
dc.contributor.authorHeise, Mark T.
dc.contributor.authorTupanceska, Daniela
dc.contributor.authorZaid, Ali
dc.contributor.authorWilmes, Anja
dc.contributor.authorGilmore, Kerry
dc.contributor.authorLidbury, Brett A.
dc.contributor.authorMahalingam, Surendran
dc.date.accessioned2018-12-02T23:12:32Z
dc.date.available2018-12-02T23:12:32Z
dc.date.issued2005
dc.date.modified2014-04-14T23:39:51Z
dc.identifier.issn01637258
dc.identifier.doi10.1016/j.pharmthera.2005.03.006
dc.identifier.urihttp://hdl.handle.net/10072/58387
dc.description.abstractRoss River virus (RRV) is a mosquito-borne alphavirus indigenous to Australia and the Western Pacific region and is responsible for several thousand cases of human RRV disease (RRVD) per annum. The disease primarily involves polyarthritis/arthralgia, with many patients also presenting with rash, myalgia, fever, and/or lethargy. The symptoms can be debilitating at onset, but they usually resolve within 3-6 months. Recent insights into the RRV-host relationship, associated pathology, and molecular biology of infection have generated a number of potential avenues for improved treatment. Although vaccine development has been proposed, the small market size and potential for antibody-dependent enhancement (ADE) of disease make this approach unattractive. Recent insights into the molecular basis of RRV-ADE and the virus's ability to manipulate host inflammatory and immune responses create potential new opportunities for therapeutic invention. Such interventions should overcome virus-induced dysregulation of protective host responses to promote viral clearance and/or ameliorate inflammatory immunopathology.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom329
dc.relation.ispartofpageto342
dc.relation.ispartofissue3
dc.relation.ispartofjournalPharmacology & Therapeutics
dc.relation.ispartofvolume107
dc.rights.retentionY
dc.subject.fieldofresearchMedical Virology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode110804
dc.subject.fieldofresearchcode1115
dc.titleRoss River virus: Molecular and cellular aspects of disease pathogenesis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorRulli, Nestor
gro.griffith.authorZaid, Ali
gro.griffith.authorMahalingam, Suresh


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