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  • Enhanced gametocyte formation in erythrocyte progenitor cells: a site specific adaptation by Plasmodium falciparum

    Author(s)
    Peatey, CL
    Watson, JA
    Trenholme, KR
    Brown, CL
    Nielson, L
    Guenther, M
    Timmins, N
    Watson, GS
    Gardiner, DL
    Griffith University Author(s)
    Brown, Chris L.
    Gardiner, Donald
    Trenholme, Katharine
    Year published
    2013
    Metadata
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    Abstract
    Gametocytogenesis by Plasmodium falciparum is essential for transmission of the parasite from human to mosquito, yet developing gametocytes lack expression of surface proteins required for cytoadherence. Therefore, elimination from the circulation should occur unless they are sequestered in regions of low blood flow such as the extracellular spaces of the bone marrow. Our data indicate that gametocytogenesis is enhanced in the presence of erythroid progenitors found within the bone marrow. Furthermore, atomic force microscopy indicates that developing gametocytes undergo remarkable shifts in their erythrocyte membrane ...
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    Gametocytogenesis by Plasmodium falciparum is essential for transmission of the parasite from human to mosquito, yet developing gametocytes lack expression of surface proteins required for cytoadherence. Therefore, elimination from the circulation should occur unless they are sequestered in regions of low blood flow such as the extracellular spaces of the bone marrow. Our data indicate that gametocytogenesis is enhanced in the presence of erythroid progenitors found within the bone marrow. Furthermore, atomic force microscopy indicates that developing gametocytes undergo remarkable shifts in their erythrocyte membrane elasticity, which may allow them to be retained within the bone marrow until maturation.
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    Journal Title
    Journal of Infectious Diseases
    Volume
    208
    DOI
    https://doi.org/10.1093/infdis/jit309
    Subject
    Biological sciences
    Cell development, proliferation and death
    Cellular interactions (incl. adhesion, matrix, cell wall)
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/58397
    Collection
    • Journal articles

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