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dc.contributor.authorPeatey, CL
dc.contributor.authorWatson, JA
dc.contributor.authorTrenholme, KR
dc.contributor.authorBrown, CL
dc.contributor.authorNielson, L
dc.contributor.authorGuenther, M
dc.contributor.authorTimmins, N
dc.contributor.authorWatson, GS
dc.contributor.authorGardiner, DL
dc.date.accessioned2017-05-03T11:28:12Z
dc.date.available2017-05-03T11:28:12Z
dc.date.issued2013
dc.date.modified2014-04-14T23:45:00Z
dc.identifier.issn0022-1899
dc.identifier.doi10.1093/infdis/jit309
dc.identifier.urihttp://hdl.handle.net/10072/58397
dc.description.abstractGametocytogenesis by Plasmodium falciparum is essential for transmission of the parasite from human to mosquito, yet developing gametocytes lack expression of surface proteins required for cytoadherence. Therefore, elimination from the circulation should occur unless they are sequestered in regions of low blood flow such as the extracellular spaces of the bone marrow. Our data indicate that gametocytogenesis is enhanced in the presence of erythroid progenitors found within the bone marrow. Furthermore, atomic force microscopy indicates that developing gametocytes undergo remarkable shifts in their erythrocyte membrane elasticity, which may allow them to be retained within the bone marrow until maturation.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1170
dc.relation.ispartofpageto1174
dc.relation.ispartofjournalJournal of Infectious Diseases
dc.relation.ispartofvolume208
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchCell development, proliferation and death
dc.subject.fieldofresearchCellular interactions (incl. adhesion, matrix, cell wall)
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode310102
dc.subject.fieldofresearchcode310105
dc.subject.fieldofresearchcode32
dc.titleEnhanced gametocyte formation in erythrocyte progenitor cells: a site specific adaptation by Plasmodium falciparum
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorBrown, Chris L.
gro.griffith.authorGardiner, Donald
gro.griffith.authorTrenholme, Katharine


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