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dc.contributor.authorFoxwell, AR
dc.contributor.authorKyd, JM
dc.contributor.authorCripps, AW
dc.date.accessioned2006-06-22
dc.date.accessioned2014-04-14T23:45:53Z
dc.date.accessioned2017-03-02T00:01:28Z
dc.date.available2017-03-02T00:01:28Z
dc.date.issued2001
dc.date.modified2014-04-14T23:45:53Z
dc.identifier.issn0264-410X
dc.identifier.doi10.1016/S0264-410X(00)00483-7
dc.identifier.urihttp://hdl.handle.net/10072/58398
dc.description.abstractInflammation is essential to repair tissue damaged by physical, microbial or allergic mechanisms. Inappropriately zealous responses lead to destructive pathology or chronic disease cycles, whereas ideal outcomes are associated with complete and rapid restoration of tissue structure and function. The establishment of a rodent model investigating the different immune responses to non-typeable Haemophilus influenzae infection in both the lung and the ear indicate an ability to clear bacteria and reduce inflammation following mucosal immunisation. Lung histochemistry, upregulaion of macrophages and polymorphonuclear neutrophils, recruitment of γδ+ and CD8+ T cells, cytokine levels and depletion studies all support the hypothesis that mucosal immunisation facilitates control of the immune response resulting in enhanced bacterial clearance and programming of inflammation which limits damage and promotes the rapid restoration of structural normality.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.publisherElsevier Ltd
dc.publisher.placeNetherlands
dc.relation.ispartofpagefrom2522
dc.relation.ispartofpageto2526
dc.relation.ispartofjournalVaccine
dc.relation.ispartofvolume19
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titleProgrammed inflammatory processes induced by mucosal immunisation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyGriffith Health Faculty
gro.date.issued2001
gro.hasfulltextNo Full Text
gro.griffith.authorCripps, Allan W.


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