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  • Adrenal pheochromocytoma remains a frequently overlooked diagnosis.

    Author(s)
    Lo, CY
    Lam, KY
    Wat, MS
    Lam, KS
    Griffith University Author(s)
    Lam, Alfred K.
    Year published
    2000
    Metadata
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    Abstract
    Background: Adrenal pheochromocytoma is potentially lethal if undetected and is associated with long-term morbidity. Methods: Records of patients (11 men, 18 women) with confirmed pheochromocytoma were studied with respect to clinicopathological features and outcome. Results: Pheochromocytoma was diagnosed in 4 of 8,486 (0.05%) autopsies and accounted for 3 of the 4 immediate causes of death. Operative mortality occurred in 1 patient with undiagnosed tumor. Hypertensive-related complications occurred in 6 patients before diagnosis. Malignancy was documented in 7 patients with distant metastases (n = 4) or locally invasive ...
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    Background: Adrenal pheochromocytoma is potentially lethal if undetected and is associated with long-term morbidity. Methods: Records of patients (11 men, 18 women) with confirmed pheochromocytoma were studied with respect to clinicopathological features and outcome. Results: Pheochromocytoma was diagnosed in 4 of 8,486 (0.05%) autopsies and accounted for 3 of the 4 immediate causes of death. Operative mortality occurred in 1 patient with undiagnosed tumor. Hypertensive-related complications occurred in 6 patients before diagnosis. Malignancy was documented in 7 patients with distant metastases (n = 4) or locally invasive tumors (n = 3). During a median follow-up of 4 years, 23 patients are alive and free of disease (79%). Four of the 6 patients (67%) who died had distant metastases compared with 2 of 23 patients (9%) without distant metastases (P = 0.04). Persistent hypertension and diabetes requiring treatment were present in 8 (35%) and 4 (17%) of 23 patients respectively. Conclusions: Fatal complications preceded diagnosis in a significant proportion of patients with pheochromocytoma. The presence of distant metastases was associated with poor survival.
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    Journal Title
    The American Journal of Surgery
    Volume
    179
    Issue
    3
    DOI
    https://doi.org/10.1016/S0002-9610(00)00296-8
    Subject
    Clinical sciences
    Publication URI
    http://hdl.handle.net/10072/58416
    Collection
    • Journal articles

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