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dc.contributor.authorLo, CY
dc.contributor.authorLam, KY
dc.contributor.authorWat, MS
dc.contributor.authorLam, KS
dc.contributor.editorKI Bland
dc.date.accessioned2006-07-07
dc.date.accessioned2017-03-02T00:01:36Z
dc.date.available2015-06-05T04:22:37Z
dc.date.available2017-03-02T00:01:36Z
dc.date.issued2000
dc.identifier.issn0002-9610
dc.identifier.doi10.1016/S0002-9610(00)00296-8
dc.identifier.urihttp://hdl.handle.net/10072/58416
dc.description.abstractBackground: Adrenal pheochromocytoma is potentially lethal if undetected and is associated with long-term morbidity. Methods: Records of patients (11 men, 18 women) with confirmed pheochromocytoma were studied with respect to clinicopathological features and outcome. Results: Pheochromocytoma was diagnosed in 4 of 8,486 (0.05%) autopsies and accounted for 3 of the 4 immediate causes of death. Operative mortality occurred in 1 patient with undiagnosed tumor. Hypertensive-related complications occurred in 6 patients before diagnosis. Malignancy was documented in 7 patients with distant metastases (n = 4) or locally invasive tumors (n = 3). During a median follow-up of 4 years, 23 patients are alive and free of disease (79%). Four of the 6 patients (67%) who died had distant metastases compared with 2 of 23 patients (9%) without distant metastases (P = 0.04). Persistent hypertension and diabetes requiring treatment were present in 8 (35%) and 4 (17%) of 23 patients respectively. Conclusions: Fatal complications preceded diagnosis in a significant proportion of patients with pheochromocytoma. The presence of distant metastases was associated with poor survival.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom212
dc.relation.ispartofpageto215
dc.relation.ispartofissue3
dc.relation.ispartofjournalThe American Journal of Surgery
dc.relation.ispartofvolume179
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1103
dc.titleAdrenal pheochromocytoma remains a frequently overlooked diagnosis.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyGriffith Health Faculty
gro.date.issued2015-06-05T04:22:37Z
gro.hasfulltextNo Full Text
gro.griffith.authorLam, Alfred K.


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