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dc.contributor.authorWilson, JC
dc.contributor.authorvon Itzstein, M
dc.contributor.editorFrancis J Castellino
dc.date.accessioned2017-05-03T11:05:52Z
dc.date.available2017-05-03T11:05:52Z
dc.date.issued2003
dc.date.modified2012-02-10T02:56:21Z
dc.identifier.issn1389-4501
dc.identifier.urihttp://hdl.handle.net/10072/5842
dc.description.abstractInfluenza is a highly contagious, acute upper respiratory tract disease caused by influenza virus, a member of the Orthomyxoviridae family. The viral particles have two surface antigens, haemagglutinin and sialidase (neuraminidase) that extensively decorate the surface of the virus and have been implicated in viral attachment and fusion, and the release of virion progeny, respectively. The receptor for haemagglutinin is the terminal sialic acid residue of host cell surface sialyloligosaccharides, while sialidase catalyses the hydrolysis of terminal sialic acid residues from sialyloligosaccharides. Extensive crystallographic studies of both these proteins have revealed that the residues that interact with the sialic acid are strictly conserved. Therefore, these proteins make attractive targets for the design of drugs to halt the progression of the virus. Recent successful efforts in the search for new cures for influenza have led to the development of three clinically-useful anti-influenza drugs. All three are potent, selective inhibitors of influenza virus A and B sialidase. Strategies for the development of haemagglutinin inhibitors have also been devised.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBentham Science Publishers
dc.publisher.placeThe Netherlands
dc.publisher.urihttp://www.bentham.org/cdt/
dc.publisher.urihttp://www.bentham.org/cdt/contabs/cdt4-5.htm##link4
dc.relation.ispartofpagefrom389
dc.relation.ispartofpageto408
dc.relation.ispartofissue5
dc.relation.ispartofjournalCurrent Drug Targets
dc.relation.ispartofvolume4
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3214
dc.titleRecent strategies in the search for new anti-influenza therapies
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.rights.copyright© 2003 Bentham Science Publishers. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorvon Itzstein, Mark
gro.griffith.authorWilson, Jenny C.


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