Show simple item record

dc.contributor.authorWilson, Jennyen_US
dc.contributor.authorvon Itzstein, Marken_US
dc.contributor.editorFrancis J Castellinoen_US
dc.date.accessioned2017-04-24T07:56:39Z
dc.date.available2017-04-24T07:56:39Z
dc.date.issued2003en_US
dc.date.modified2012-02-10T02:56:21Z
dc.identifier.issn1389-4501en_US
dc.identifier.doihttp://www.bentham.org/cdt/contabs/cdt4-5.htm##link4en_US
dc.identifier.urihttp://hdl.handle.net/10072/5842
dc.description.abstractInfluenza is a highly contagious, acute upper respiratory tract disease caused by influenza virus, a member of the Orthomyxoviridae family. The viral particles have two surface antigens, haemagglutinin and sialidase (neuraminidase) that extensively decorate the surface of the virus and have been implicated in viral attachment and fusion, and the release of virion progeny, respectively. The receptor for haemagglutinin is the terminal sialic acid residue of host cell surface sialyloligosaccharides, while sialidase catalyses the hydrolysis of terminal sialic acid residues from sialyloligosaccharides. Extensive crystallographic studies of both these proteins have revealed that the residues that interact with the sialic acid are strictly conserved. Therefore, these proteins make attractive targets for the design of drugs to halt the progression of the virus. Recent successful efforts in the search for new cures for influenza have led to the development of three clinically-useful anti-influenza drugs. All three are potent, selective inhibitors of influenza virus A and B sialidase. Strategies for the development of haemagglutinin inhibitors have also been devised.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherBentham Science Publishersen_US
dc.publisher.placeThe Netherlandsen_US
dc.publisher.urihttp://www.bentham.org/cdt/en_US
dc.relation.ispartofpagefrom389en_US
dc.relation.ispartofpageto408en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalCurrent Drug Targetsen_US
dc.relation.ispartofvolume4en_US
dc.subject.fieldofresearchcode250301en_US
dc.titleRecent strategies in the search for new anti-influenza therapiesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, School of Natural Sciencesen_US
gro.rights.copyrightCopyright 2003 Bentham Science Publishers. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2003
gro.hasfulltextNo Full Text


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record