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  • Immune Abnormalities in Patients Meeting New Diagnostic Criteria for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

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    Author(s)
    Brenu, Ekua
    Johnston, Samantha
    Hardcastle, Sharni
    Huth, Teilah
    Fuller, Kirsty
    Ramos, Sandra
    Staines, Don
    Marshall-Gradisnik, Sonya
    Griffith University Author(s)
    Staines, Don R.
    Hardcastle, Sharni L.
    Huth, Teilah K.
    Ramos, Sandra B.
    Marshall-Gradisnik, Sonya M.
    Johnston, Samantha
    Brenu, Ekua
    Fuller, Kirsty
    Year published
    2013
    Metadata
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    Abstract
    Background: Immunological abnormalities have been identified in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients fulfilling the 1994 Centers for Disease Control diagnostic criteria. Significant developments have been made to diagnostic criteria, but potential immunological markers have not been assessed in patients fulfilling these latest clinical requirements. Therefore, this study evaluated immunological parameters in patients that also fulfill the latest diagnostic criteria available known as the International Consensus Criteria. Methods: The Immunological investigations including Natural Killer cell activity ...
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    Background: Immunological abnormalities have been identified in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients fulfilling the 1994 Centers for Disease Control diagnostic criteria. Significant developments have been made to diagnostic criteria, but potential immunological markers have not been assessed in patients fulfilling these latest clinical requirements. Therefore, this study evaluated immunological parameters in patients that also fulfill the latest diagnostic criteria available known as the International Consensus Criteria. Methods: The Immunological investigations including Natural Killer cell activity and phenotyping studies for dendritic cells, neutrophils, B cells and regulatory T cells were performed on whole blood samples collected from all participants using flow cytometric protocols. The physical functioning of all participants was also evaluated using scores from the Short Form Health Survey, and the World Health Organization Disability Adjustment Schedule. Results were compared according 1994 Centers of Disease Control and Prevention defined patients, and International Consensus Criteria defined patients, and healthy controls. Results: Natural killer cell activity was consistently and significantly decreased, and regulatory T cells were significantly increased in both patient groups compared to healthy controls. Differences were found in human neutraphil antigens and expression of natural killer cell receptors between patient groups. Highly significant correlations were also found between physical status and some immune parameters in International Consensus Criteria defined patients. Conclusion: This preliminary investigation on different diagnostic criteria suggests that the International Consensus Criteria may be more effective a detecting salient differences in the immune system.
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    Journal Title
    Journal of Molecular Biomarkers & Diagnosis
    Volume
    4
    Issue
    3
    DOI
    https://doi.org/10.4172/2155-9929.1000152
    Copyright Statement
    © The Author(s) 2013. For information about this journal please refer to the publisher’s website or contact the author[s]. Articles are licensed under the terms of the Creative Commons Attribution 2.0 Generic (CC BY 2.0) license (http://creativecommons.org/licenses/by/2.0/) which permits unrestricted distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Immunology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/58585
    Collection
    • Journal articles

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