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  • Analysis of 3 common polymorphisms in the KCNK18 gene in an Australian Migraine Case-control cohort

    Author(s)
    Maher, BH
    Taylor, M
    Stuart, S
    Okolicsanyi, RK
    Roy, B
    Sutherland, HG
    Haupt, LM
    Griffiths, LR
    Griffith University Author(s)
    Haupt, Larisa
    Griffiths, Lyn
    Taylor, Matthew I.
    Okolicsanyi, Rachel
    Maher, Bridget
    Roy, Bishakha
    Sutherland, Heidi
    Stuart, Shani
    Year published
    2013
    Metadata
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    Abstract
    Migraine is a common neurological disorder characterised by temporary disabling attacks of severe head pain and associated disturbances. There is significant evidence to suggest a genetic aetiology to the disease however few causal mutations have been conclusively linked to the migraine subtypes Migraine with (MA) or without Aura (MO). The Potassium Channel, Subfamily K, member 18 (KCNK18) gene, coding the potassium channel TRESK, is the first gene in which a rare mutation resulting in a non-functional truncated protein has been identified and causally linked to MA in a multigenerational family. In this study, three common ...
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    Migraine is a common neurological disorder characterised by temporary disabling attacks of severe head pain and associated disturbances. There is significant evidence to suggest a genetic aetiology to the disease however few causal mutations have been conclusively linked to the migraine subtypes Migraine with (MA) or without Aura (MO). The Potassium Channel, Subfamily K, member 18 (KCNK18) gene, coding the potassium channel TRESK, is the first gene in which a rare mutation resulting in a non-functional truncated protein has been identified and causally linked to MA in a multigenerational family. In this study, three common polymorphisms in the KCNK18 gene were analysed for genetic variation in an Australian case-control migraine population consisting of 340 migraine cases and 345 controls. No association was observed for the polymorphisms examined with the migraine phenotype or with any haplotypes across the gene. Therefore even though the KCNK18 gene is the only gene to be causally linked to MA our studies indicate that common genetic variation in the gene is not a contributor to MA.
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    Journal Title
    Gene
    Volume
    528
    Issue
    2
    DOI
    https://doi.org/10.1016/j.gene.2013.07.030
    Subject
    Genetics
    Zoology
    Medical microbiology
    Publication URI
    http://hdl.handle.net/10072/58593
    Collection
    • Journal articles

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