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dc.contributor.authorMaher, BH
dc.contributor.authorTaylor, M
dc.contributor.authorStuart, S
dc.contributor.authorOkolicsanyi, RK
dc.contributor.authorRoy, B
dc.contributor.authorSutherland, HG
dc.contributor.authorHaupt, LM
dc.contributor.authorGriffiths, LR
dc.date.accessioned2017-05-03T15:36:08Z
dc.date.available2017-05-03T15:36:08Z
dc.date.issued2013
dc.date.modified2014-04-16T23:05:23Z
dc.identifier.issn0378-1119
dc.identifier.doi10.1016/j.gene.2013.07.030
dc.identifier.urihttp://hdl.handle.net/10072/58593
dc.description.abstractMigraine is a common neurological disorder characterised by temporary disabling attacks of severe head pain and associated disturbances. There is significant evidence to suggest a genetic aetiology to the disease however few causal mutations have been conclusively linked to the migraine subtypes Migraine with (MA) or without Aura (MO). The Potassium Channel, Subfamily K, member 18 (KCNK18) gene, coding the potassium channel TRESK, is the first gene in which a rare mutation resulting in a non-functional truncated protein has been identified and causally linked to MA in a multigenerational family. In this study, three common polymorphisms in the KCNK18 gene were analysed for genetic variation in an Australian case-control migraine population consisting of 340 migraine cases and 345 controls. No association was observed for the polymorphisms examined with the migraine phenotype or with any haplotypes across the gene. Therefore even though the KCNK18 gene is the only gene to be causally linked to MA our studies indicate that common genetic variation in the gene is not a contributor to MA.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom343
dc.relation.ispartofpageto346
dc.relation.ispartofissue2
dc.relation.ispartofjournalGene
dc.relation.ispartofvolume528
dc.rights.retentionY
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3105
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3207
dc.titleAnalysis of 3 common polymorphisms in the KCNK18 gene in an Australian Migraine Case-control cohort
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorHaupt, Larisa
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorTaylor, Matthew I.
gro.griffith.authorOkolicsanyi, Rachel
gro.griffith.authorMaher, Bridget
gro.griffith.authorRoy, Bishakha
gro.griffith.authorSutherland, Heidi
gro.griffith.authorStuart, Shani


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