Effects of gamma-tocopherol supplementation on thrombotic risk factors
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Author(s)
Singh, Indu
Turner, Alan H
Sinclair, Andrew J
Li, Duo
Hawley, John A
Griffith University Author(s)
Year published
2007
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Objective: The antioxidant activity of vitamin E is derived primarily from alpha-tocopherol (a-T) and gammatocopherol (?-T). Results of epidemiological studies have demonstrated an inverse relationship between vitamin E intake and coronary disease. However, the results of clinical trials using a-T are equivocal. We determined the effect of 5 weeks of 100 mg/d or 200 mg/d ?-T supplementation on thrombotic markers such as platelet reactivity, lipid profile and the inflammation marker C-reactive protein (CRP). Methods and results: Fourteen healthy subjects consumed 100 mg/day while 13 consumed 200 mg/d of ?-T and 12 received ...
View more >Objective: The antioxidant activity of vitamin E is derived primarily from alpha-tocopherol (a-T) and gammatocopherol (?-T). Results of epidemiological studies have demonstrated an inverse relationship between vitamin E intake and coronary disease. However, the results of clinical trials using a-T are equivocal. We determined the effect of 5 weeks of 100 mg/d or 200 mg/d ?-T supplementation on thrombotic markers such as platelet reactivity, lipid profile and the inflammation marker C-reactive protein (CRP). Methods and results: Fourteen healthy subjects consumed 100 mg/day while 13 consumed 200 mg/d of ?-T and 12 received placebo (soybean capsules with less than 5 mg/d ?-T) in a double-blinded parallel study design. Fasting pre and post dose blood samples were analysed. Blood ?-T concentrations increased significantly (p<0.05) relative to dose during the intervention period. Both groups receiving active ingredients showed significantly lower platelet activation after supplementation (p<0.05). Subjects consuming 100 mg/d ?-T had significantly decreased LDL cholesterol, platelet aggregation and mean platelet volume (MPV) (p<0.05). Little effect of ?-T was observed on other parameters. Conclusions: These data suggest that ?-T supplementation may have a permissive role in decreasing the risk of thrombotic events by improving lipid profile and reducing platelet activity.
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View more >Objective: The antioxidant activity of vitamin E is derived primarily from alpha-tocopherol (a-T) and gammatocopherol (?-T). Results of epidemiological studies have demonstrated an inverse relationship between vitamin E intake and coronary disease. However, the results of clinical trials using a-T are equivocal. We determined the effect of 5 weeks of 100 mg/d or 200 mg/d ?-T supplementation on thrombotic markers such as platelet reactivity, lipid profile and the inflammation marker C-reactive protein (CRP). Methods and results: Fourteen healthy subjects consumed 100 mg/day while 13 consumed 200 mg/d of ?-T and 12 received placebo (soybean capsules with less than 5 mg/d ?-T) in a double-blinded parallel study design. Fasting pre and post dose blood samples were analysed. Blood ?-T concentrations increased significantly (p<0.05) relative to dose during the intervention period. Both groups receiving active ingredients showed significantly lower platelet activation after supplementation (p<0.05). Subjects consuming 100 mg/d ?-T had significantly decreased LDL cholesterol, platelet aggregation and mean platelet volume (MPV) (p<0.05). Little effect of ?-T was observed on other parameters. Conclusions: These data suggest that ?-T supplementation may have a permissive role in decreasing the risk of thrombotic events by improving lipid profile and reducing platelet activity.
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Journal Title
Asia Pacific Journal of Clinical Nutrition
Volume
16
Issue
3
Copyright Statement
© 2007 HEC Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Cardiovascular medicine and haematology not elsewhere classified
Nutrition and dietetics