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dc.contributor.authorLam, KY
dc.contributor.authorChan, ACL
dc.contributor.authorLo, CY
dc.contributor.editorDr. Arthur Tischler
dc.date.accessioned2006-07-07
dc.date.accessioned2017-03-02T01:10:50Z
dc.date.available2015-06-05T03:54:56Z
dc.date.available2017-03-02T01:10:50Z
dc.date.issued2000
dc.identifier.issn1046-3976
dc.identifier.doi10.1385/EP:11:1:77
dc.identifier.urihttp://hdl.handle.net/10072/58803
dc.description.abstractPronounced lymphocytic infiltration in parathyroid adenoma is rare, with only six previously reported cases in the literature. The aims of this study are to review the features and investigate the pathogenesis of this rare entity. Two solitary parathyroid adenomas having this feature were reported, and the clinicopathologic features of all the documented cases were reviewed. The nature of the lymphoid infiltrate and the presence of Epstein-Barr virus (EBV) were analyzed to unveil the pathogenesis of this infiltrate. One ademona was found in a 70-yr-old woman with primary hyperparathyroidism and valvular heart disease. The other was an autopsy finding in a 48-yr-old man who had presented with hypercalcemic crisis. The lymphoid cell population within the tumors was composed of B cells and different subsets of T cells. EBV was not detected in the infiltrates. The lymphocytic infiltrate in parathyroid adenoma is an unusual histologic entity. Its presence is unlikely to imply an autoimmune disorder. We hypothesize that the lesion may be a result of local tissue response to parathyroid adenoma.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherHumana Press
dc.publisher.placeUSA
dc.relation.ispartofpagefrom77
dc.relation.ispartofpageto83
dc.relation.ispartofjournalEndocrine Pathology
dc.relation.ispartofvolume11
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleParathyroid adenomas with pronounced lymphocytic infiltration: no evidence of autoimmune pathogenesis.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyGriffith Health Faculty
gro.date.issued2015-06-05T03:54:56Z
gro.hasfulltextNo Full Text
gro.griffith.authorLam, Alfred K.


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