E-commerce for the non-profit organisations is a relatively new research niche in the general e-commerce stream. It denotes the use of e-commerce by not-for-profit organisations to reduce their expenses or to improve their operations and customer service. A survey of Malaysian universities was conducted to determine the key factors that facilitate the adoption of e-commerce. Sixty-five schools and centres responded to the survey and supplied usable data for the study. Factor and regression analyses were conducted. From the factor analysis, five factors emerged namely, relative advantage, network orientation, information efficiency, innovativeness and competitiveness. The regression result identified three dimensions with significant relationship with adoption; they are relative advantage, network orientation and information efficiency. Implications of the findings are discussed.