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  • Cylindrospermopsin, a cyanobacterial alkaloid: Evaluation of its toxicological activity.

    Author(s)
    Shaw, Glendon Reginald
    Seawright, A.A.
    Moore, M.R.
    Lam, P.K.S.
    Griffith University Author(s)
    Shaw, Glendon R.
    Year published
    2000
    Metadata
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    Abstract
    This paper describes the natural occurrence of the toxin, cylindrospermopsin, in two species of cyanobacteria found in Australia. The structure and chemical properties of this compound are described along with a nontoxic analog of cylindrospermopsin. The results of both intraperitoneal (IP) and oral dosing of mice show that hepatotoxicity is the main effect of cylindrospermopsin in vivo, but that a thrombohemorrhagic phenomenon is observed in a proportion of dosed animals. It has been shown that the toxin can be metabolized in vivo and that a bound metabolite occurs in the liver. Cytotoxicity experiments using cell cultures ...
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    This paper describes the natural occurrence of the toxin, cylindrospermopsin, in two species of cyanobacteria found in Australia. The structure and chemical properties of this compound are described along with a nontoxic analog of cylindrospermopsin. The results of both intraperitoneal (IP) and oral dosing of mice show that hepatotoxicity is the main effect of cylindrospermopsin in vivo, but that a thrombohemorrhagic phenomenon is observed in a proportion of dosed animals. It has been shown that the toxin can be metabolized in vivo and that a bound metabolite occurs in the liver. Cytotoxicity experiments using cell cultures show that cylindrospermopsin is more cytotoxic to isolated rat liver hepatocytes than to other cell types. Risk assessment calculations show that guideline values for cylindrospermopsin in drinking water should lie in the low microgram per liter range.
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    Journal Title
    Therapeutic Drug Monitoring
    Volume
    22
    Issue
    1
    Publisher URI
    http://journals.lww.com/drug-monitoring/Abstract/2000/02000/Cylindrospermopsin,_A_Cyanobacterial_Alkaloid_.19.aspx
    Subject
    Analytical Chemistry
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/58884
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    • Journal articles

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