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dc.contributor.authorShaw, Glendon Reginalden_US
dc.contributor.authorSeawright, A.A.en_US
dc.contributor.authorMoore, M.R.en_US
dc.contributor.authorLam, P.K.S.en_US
dc.date.accessioned2006-07-20en_US
dc.date.accessioned2014-04-30T23:16:14Z
dc.date.accessioned2017-03-02T00:13:41Z
dc.date.available2017-03-02T00:13:41Z
dc.date.issued2000en_US
dc.date.modified2014-04-30T23:16:14Z
dc.identifier.issn0163-4356en_US
dc.identifier.urihttp://hdl.handle.net/10072/58884
dc.description.abstractThis paper describes the natural occurrence of the toxin, cylindrospermopsin, in two species of cyanobacteria found in Australia. The structure and chemical properties of this compound are described along with a nontoxic analog of cylindrospermopsin. The results of both intraperitoneal (IP) and oral dosing of mice show that hepatotoxicity is the main effect of cylindrospermopsin in vivo, but that a thrombohemorrhagic phenomenon is observed in a proportion of dosed animals. It has been shown that the toxin can be metabolized in vivo and that a bound metabolite occurs in the liver. Cytotoxicity experiments using cell cultures show that cylindrospermopsin is more cytotoxic to isolated rat liver hepatocytes than to other cell types. Risk assessment calculations show that guideline values for cylindrospermopsin in drinking water should lie in the low microgram per liter range.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.publisher.placeUSAen_US
dc.publisher.urihttp://journals.lww.com/drug-monitoring/Abstract/2000/02000/Cylindrospermopsin,_A_Cyanobacterial_Alkaloid_.19.aspxen_US
dc.relation.ispartofpagefrom89en_US
dc.relation.ispartofpageto92en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalTherapeutic Drug Monitoringen_US
dc.relation.ispartofvolume22en_US
dc.subject.fieldofresearchPRE2009-Environmental and Occupational Health and Safetyen_US
dc.subject.fieldofresearchcode321201en_US
dc.titleCylindrospermopsin, a cyanobacterial alkaloid: Evaluation of its toxicological activity.en_US
dc.typeJournal article
dc.type.descriptionArticle in Scholarly Refereed Journalen_US
dc.type.codec1xen_US
gro.facultyGriffith Health Facultyen_US
gro.date.issued2000
gro.hasfulltextNo Full Text
gro.griffith.authorShaw, Glendon R.


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