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  • Transport of endosomal early antigen 1 in the rat sciatic nerve and location in cultured neurons.

    Author(s)
    Weible, Michael
    Griffith University Author(s)
    Weible, Michael W.
    Year published
    2001
    Metadata
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    Abstract
    Early endosomal antigen 1 (EEA1) is known to be a marker of early endosomes and in cultured hippocampal neurons it preferentially localizes to the dendritic but not the axonal compartment. We show in cultured dorsal root ganglia and superior cervical ganglia neurons that EEA1 localizes to the cell bodies and the neurites of both sensory and sympathetic neurons. We then show in vivo using a ligated rat sciatic nerve that EEA1 significantly accumulates on the proximal side and not on the distal side of the ligation. This suggests that EEA1 is transported in the anterograde direction in axons either as part of the homeostatic ...
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    Early endosomal antigen 1 (EEA1) is known to be a marker of early endosomes and in cultured hippocampal neurons it preferentially localizes to the dendritic but not the axonal compartment. We show in cultured dorsal root ganglia and superior cervical ganglia neurons that EEA1 localizes to the cell bodies and the neurites of both sensory and sympathetic neurons. We then show in vivo using a ligated rat sciatic nerve that EEA1 significantly accumulates on the proximal side and not on the distal side of the ligation. This suggests that EEA1 is transported in the anterograde direction in axons either as part of the homeostatic process or to the nerve ligation site in response to nerve injury.
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    Journal Title
    Neuroreport
    Volume
    12
    Issue
    2
    Publisher URI
    http://journals.lww.com/neuroreport/Abstract/2001/02120/Transport_of_endosomal_early_antigen_1_in_the_rat.20.aspx
    Subject
    Cellular Nervous System
    Neurosciences
    Cognitive Sciences
    Publication URI
    http://hdl.handle.net/10072/58888
    Collection
    • Journal articles

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