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dc.contributor.authorWeible, Michael
dc.date.accessioned2011-08-07
dc.date.accessioned2014-04-30T23:18:19Z
dc.date.accessioned2017-03-02T00:13:43Z
dc.date.available2017-03-02T00:13:43Z
dc.date.issued2001
dc.date.modified2014-04-30T23:18:19Z
dc.identifier.issn0959-4965
dc.identifier.urihttp://hdl.handle.net/10072/58888
dc.description.abstractEarly endosomal antigen 1 (EEA1) is known to be a marker of early endosomes and in cultured hippocampal neurons it preferentially localizes to the dendritic but not the axonal compartment. We show in cultured dorsal root ganglia and superior cervical ganglia neurons that EEA1 localizes to the cell bodies and the neurites of both sensory and sympathetic neurons. We then show in vivo using a ligated rat sciatic nerve that EEA1 significantly accumulates on the proximal side and not on the distal side of the ligation. This suggests that EEA1 is transported in the anterograde direction in axons either as part of the homeostatic process or to the nerve ligation site in response to nerve injury.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.publisherLippincott Williams & Wilkins
dc.publisher.placeEngland
dc.publisher.urihttp://journals.lww.com/neuroreport/Abstract/2001/02120/Transport_of_endosomal_early_antigen_1_in_the_rat.20.aspx
dc.relation.ispartofpagefrom281
dc.relation.ispartofpageto284
dc.relation.ispartofissue2
dc.relation.ispartofjournalNeuroreport
dc.relation.ispartofvolume12
dc.subject.fieldofresearchCellular Nervous System
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode110902
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1702
dc.titleTransport of endosomal early antigen 1 in the rat sciatic nerve and location in cultured neurons.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyFaculty of Science, Environment, Engineering and Technology
gro.date.issued2001
gro.hasfulltextNo Full Text
gro.griffith.authorWeible, Michael W.


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