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  • Oropharyngeal pemphigus in a patient with chronic hepatitis C during interferon alphs-2a therapy.

    Author(s)
    Marinho, RT
    Johnson, NW
    Fatela, NM
    Serejo, FS
    Gloria, H
    Raimundo, MO
    Velosa, JF
    Ramalho, FJ
    Moura, MC
    Griffith University Author(s)
    Johnson, Newell W.
    Year published
    2001
    Metadata
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    Abstract
    There are a few reports in the literature concerning pemphigus induced by interferon given for hepatitis C. We present the case of a 28-year-old woman with post-transfusional chronic hepatitis C who developed ulcers and vesicles on her tongue, cheeks, posterior oropharynx and vocal cords 5 months after beginning treatment with recombinant interferon alpha-2a. The direct and indirect immunofluorescence was diagnostic of pemphigus vulgaris. The drug was promptly withdrawn; the patient was medicated with prednisolone and azathioprine and recovered only 3 months later. Although there are several publications describing the ...
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    There are a few reports in the literature concerning pemphigus induced by interferon given for hepatitis C. We present the case of a 28-year-old woman with post-transfusional chronic hepatitis C who developed ulcers and vesicles on her tongue, cheeks, posterior oropharynx and vocal cords 5 months after beginning treatment with recombinant interferon alpha-2a. The direct and indirect immunofluorescence was diagnostic of pemphigus vulgaris. The drug was promptly withdrawn; the patient was medicated with prednisolone and azathioprine and recovered only 3 months later. Although there are several publications describing the occurrence of other autoimmune diseases in patients receiving interferon alpha therapy, this is the first report of a pemphigus induced by interferon in hepatitis C patients involving oropharyngeal and laryngeal mucosae without cutaneous involvement.
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    Journal Title
    European Journal of Gastroenterology and Hepatology
    Volume
    13
    Issue
    7
    Publisher URI
    http://journals.lww.com/eurojgh/Abstract/2001/07000/Oropharyngeal_pemphigus_in_a_patient_with_chronic.17.aspx
    Subject
    Clinical Sciences
    Publication URI
    http://hdl.handle.net/10072/58901
    Collection
    • Journal articles

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