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  • A genome screen for multiple sclerosis in Sardinian multiplex families

    Author(s)
    Coraddu, F
    Sawcer, S
    D'Alfonso, S
    Lai, M
    Hensiek, A
    Solla, E
    Broadley, S
    Mancosu, C
    Pugliatti, M
    Marrosu, MG
    Compston, A
    Griffith University Author(s)
    Broadley, Simon
    Year published
    2001
    Metadata
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    Abstract
    The prevalence of multiple sclerosis in Sardinia is significantly higher than in neighbouring Mediterranean countries, suggesting that the isolated growth of the population has concentrated genetic factors which increase susceptibility to the disease. The distinct HLA association of multiple sclerosis in Sardinia supports this interpretation. We have performed a whole genome screen for linkage in 49 Sardinian multiplex families using 327 markers. Non parametric linkage analysis of these data reveal suggestive linkage in the region of Chr 1q31, Chr 10q23 and Chr 11p15.The prevalence of multiple sclerosis in Sardinia is significantly higher than in neighbouring Mediterranean countries, suggesting that the isolated growth of the population has concentrated genetic factors which increase susceptibility to the disease. The distinct HLA association of multiple sclerosis in Sardinia supports this interpretation. We have performed a whole genome screen for linkage in 49 Sardinian multiplex families using 327 markers. Non parametric linkage analysis of these data reveal suggestive linkage in the region of Chr 1q31, Chr 10q23 and Chr 11p15.
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    Journal Title
    European Journal of Human Genetics
    Volume
    9
    Issue
    8
    Publisher URI
    http://www.nature.com/ejhg/journal/v9/n8/abs/5200680a.html
    Subject
    Genetics
    Clinical Sciences
    Publication URI
    http://hdl.handle.net/10072/59092
    Collection
    • Journal articles

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