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dc.contributor.authorReher, VGS
dc.contributor.authorZenóbio, EG
dc.contributor.authorCosta, FO
dc.contributor.authorReher, P
dc.contributor.authorSoares, RV
dc.date.accessioned2017-05-03T15:43:26Z
dc.date.available2017-05-03T15:43:26Z
dc.date.issued2007
dc.date.modified2014-05-15T21:40:42Z
dc.identifier.issn1343-4934
dc.identifier.urihttp://hdl.handle.net/10072/59106
dc.description.abstractThe aims of this study were to compare nitric oxide (NO) levels in stimulated whole saliva from individuals with and without generalized chronic periodontitis (GCP), and to evaluate correlations between these levels with a clinical diagnostic parameter. According to specific criteria, 30 individuals were divided into three groups: one comprising individuals without periodontitis (GC), a second comprising individuals with moderate GCP (GM), and a third comprising individuals with advanced GCP (GA). Samples were collected and NO levels measured. NO in the GCP group (GM: 7.78 卻 GA: 15.79 卩 was higher than in the GC group (5.86 卩. NO levels in the GA group were significantly higher (P < 0.0001) than in the GC group, and could also differentiate (P < 0.0001) the moderate and advanced forms of the disease. In addition, positive correlations between NO level and the number of teeth with a probing depth of = 4 mm (r = 0.54) and = 7 mm (r = 0.68) were observed. In conclusion, NO levels are elevated in individuals with GPC and are correlated with a periodontal clinical parameter. These results reveal that this form of periodontal disease and its severity are related to salivary nitrite concentration, indicating that NO may serve as a potential biological marker for detection and/or monitoring of GCP.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageeng
dc.publisherNihon University
dc.publisher.placeJapan
dc.publisher.urihttp://jos.dent.nihon-u.ac.jp/isuue/index49-04.html
dc.publisher.urihttp://jos.dent.nihon-u.ac.jp/journal/49/4/271.pdf
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom271
dc.relation.ispartofpageto276
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Oral Science
dc.relation.ispartofvolume49
dc.rights.retentionN
dc.subject.fieldofresearchPeriodontics
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchcode110508
dc.subject.fieldofresearchcode1105
dc.titleNitric oxide levels in saliva increase with severity of chronic periodontitis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorReher, Vanessa G.
gro.griffith.authorReher, Peter


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