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dc.contributor.authorStewart, Trina
dc.date.accessioned2012-12-17
dc.date.accessioned2014-05-15T22:24:48Z
dc.date.accessioned2017-03-01T23:51:33Z
dc.date.available2017-03-01T23:51:33Z
dc.date.issued2004
dc.date.modified2014-05-15T22:24:48Z
dc.identifier.issn1440-1711
dc.identifier.doi10.1111/j.0818-9641.2004.01273.x
dc.identifier.urihttp://hdl.handle.net/10072/59157
dc.description.abstractImmunotherapy of tumours using T cells expanded in vitro has met with mixed clinical success suggesting that a greater understanding of tumour/T-cell interaction is required. We used a HPV16E7 oncoprotein based mouse tumour model to study this further. In this study, we demonstrate that a HPV16E7 tumour passes through at least three stages of immune susceptibility over time. At the earliest time point, infusion of intravenous immune cells fails to control tumour growth although the same cells given subcutaneously at the tumour site are effective. In a second stage, the tumour becomes resistant to subcutaneous infusion of cells but is now susceptible to both adjuvant activated and HPV16E7-specific immune cells transferred intravenously. In the last phase, the tumour is susceptible to intravenous transfer of HPV16E7-specific cells, but not adjuvant-activated immune cells. The requirement for IFN-γ and perforin also changes with each stage of tumour development. Our data suggest that effective adoptive T-cell therapy of tumour will need to be matched with the stage of tumour development.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.publisherNature Publishing Group
dc.publisher.placeAustralia
dc.relation.ispartofpagefrom455
dc.relation.ispartofpageto461
dc.relation.ispartofjournalImmunology and Cell Biology
dc.relation.ispartofvolume82
dc.subject.fieldofresearchTumour Immunology
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode110709
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1107
dc.titleTumour susceptibility to innate and adaptive immunotherapy changes during tumour maturation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyGriffith Health Faculty
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorStewart, Trina


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