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dc.contributor.authorTamasi, Joseph A
dc.contributor.authorVasilov, Anatoliy
dc.contributor.authorShimizu, Emi
dc.contributor.authorBenton, Noah
dc.contributor.authorJohnson, Joshua
dc.contributor.authorBitel, Claudine L
dc.contributor.authorMorrison, Nigel
dc.contributor.authorPartridge, Nicola C
dc.contributor.editorJuliet Compston
dc.date.accessioned2017-05-03T11:03:11Z
dc.date.available2017-05-03T11:03:11Z
dc.date.issued2013
dc.date.modified2014-09-11T01:57:42Z
dc.identifier.issn0884-0431
dc.identifier.doi10.1002/jbmr.1933
dc.identifier.urihttp://hdl.handle.net/10072/59206
dc.description.abstractParathyroid hormone (PTH) has a significant role as an anabolic hormone in bone when administered by intermittent injection. Previous microarray studies in our laboratory have shown that the most highly regulated gene, monocyte chemoattractant protein-1 (MCP-1), is rapidly and transiently induced when hPTH(1-34) is injected intermittently in rats. Through further in vivo studies, we found that rats treated with hPTH(1-34) showed a significant increase in serum MCP-1 levels 2 hours after PTH injection compared to basal levels. Using immunohistochemistry, increased MCP-1 expression in osteoblasts and osteocytes is evident after PTH treatment. PTH also increased the number of marrow macrophages. MCP-1 knockout mice injected daily with hPTH(1-34) showed less trabecular bone mineral density and bone volume compared to wild type mice as measured by pQCT and microCT. Histomorphometric analysis revealed that the increase in osteoclast surface and osteoclast number observed with intermittent PTH treatment in the wild type mice was completely eliminated in the MCP-1 null mice, as well as much lower numbers of macrophages. Consequently, the lack of osteoclast and macrophage activity in the MCP-1 null mice was paralleled by a reduction in bone formation. We conclude that osteoblast and osteocyte MCP-1 expression is an important mediator for the anabolic effects of PTH on bone.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1105955 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley Blackwell
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1975
dc.relation.ispartofpageto1986
dc.relation.ispartofissue9
dc.relation.ispartofjournalJournal of Bone and Mineral Research
dc.relation.ispartofvolume28
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode40
dc.subject.fieldofresearchcode32
dc.titleMonocyte chemoattractant protein-1 is a mediator of the anabolic action of parathyroid hormone on bone
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2013 American Society for Bone and Mineral Research. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorMorrison, Nigel A.


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