Show simple item record

dc.contributor.authorOlive, Colleen
dc.contributor.authorHo, Mei-Fong
dc.contributor.authorDyer, Joanne
dc.contributor.authorLincoln, Douglas
dc.contributor.authorBarozzi, Nadia
dc.contributor.authorToth, Istvan
dc.contributor.authorF. Good, Michael
dc.date.accessioned2017-05-03T14:53:59Z
dc.date.available2017-05-03T14:53:59Z
dc.date.issued2006
dc.date.modified2014-05-22T22:16:05Z
dc.identifier.issn00221899
dc.identifier.doi10.1086/504266
dc.identifier.urihttp://hdl.handle.net/10072/59215
dc.description.abstractBackgroundThe development of a vaccine to prevent infection with group A streptococcus (GAS) is hampered by the widespread diversity of circulating GAS strains and M protein types, and it is widely believed that a multivalent vaccine would provide better protective immunity MethodsWe investigated the efficacy of incorporating 3 M protein serotypic amino-terminal epitopes from GAS isolates that are common in Australian Aboriginal communities and a conformational epitope from the conserved carboxy-terminal C-repeat region into a single synthetic lipid core peptide (LCP) vaccine construct in inducing broadly protective immune responses against GAS after parenteral delivery to mice ResultsImmunization with the tetraepitopic LCP vaccine construct led to high titers of systemic, antigen-specific IgG responses and the induction of broadly protective immune responses, as was demonstrated by the ability of immune serum to opsonize multiple GAS strains. Systemic challenge of mice with a lethal dose of GAS given 60 or 300 days after primary immunization showed that, compared with the control mice, the vaccinated mice were significantly protected against GAS infection, demonstrating that the vaccination stimulated long-lasting protective immunity ConclusionsThese data support the efficacy of the LCP vaccine delivery system in the development of a synthetic, multiepitopic vaccine for the prevention of GAS infection
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1666
dc.relation.ispartofpageto1676
dc.relation.ispartofissue12
dc.relation.ispartofjournalJournal of Infectious Diseases
dc.relation.ispartofvolume193
dc.rights.retentionY
dc.subject.fieldofresearchMedical Microbiology not elsewhere classified
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode110899
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleImmunization with a Tetraepitopic Lipid Core Peptide Vaccine Construct Induces Broadly Protective Immune Responses against Group A Streptococcus
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record